Department Of Veterans Affairs

Understanding how macrophage immune cells accumulate in fat tissue and contribute to the pathology of obesity could lead to the development of novel therapeutics for metabolic disorders. Read More

The factor FoxM1 increases the proliferation and function of insulin-producing beta cells, making it an attractive therapeutic target for diabetes. Read More

The rigidity of the bone extracellular matrix increases the ability of tumor cells to destroy bone, suggesting new targets for anticancer drug development. Read More

An antioxidant protein may protect against colon cancer that develops in patients with inflammatory bowel disease, suggesting new strategies for reducing colon cancer risk in these patients. Read More

A new mouse model demonstrates that the Hhex gene – which is linked to blood cancers – is critical for normal blood cell production. Read More

A polymer hydrogel material developed by Vanderbilt scientists improved the delivery of stem cells for heart repair. Read More

A metabolic change in adult stem cells makes them less “fit” for regenerative heart therapies, suggesting that strategies to prevent this response may boost the therapeutic usefulness of the cells. Read More

A novel mechanism could point to new therapies for a group of inherited diseases that share pathological features. Read More

Pediatric patients have a significantly higher incidence of transfusion reactions compared to adults, according to a study by Vanderbilt University researchers. Read More

New findings suggest that it might be possible to treat diabetes by regenerating insulin-producing beta cells in the pancreas. Read More

TGF-beta signaling in the kidney was thought to be a target for reducing renal fibrosis, but Vanderbilt researchers report that fibrosis still occurs in the absence of TGF-beta signaling. Read More

Vanderbilt researchers have identified a new protein involved in heart cell growth, which could improve understanding of pathologic cardiac hypertrophy. Read More

A newly identified “atheroprotective” gene is a tool for exploring plaque pathophysiology and may be a good target for therapies to slow atherosclerosis progression. Read More

The activity of a certain factor in immune cells is essential for an anti-tumor response, emphasizing the need to consider the effects of anti-cancer therapies on immune cells. Read More

Soldiers deployed to tropical and sunny climates are coming home with increased risk factors for a threat far from the battlefield: skin cancer. Read More

The factor ATF4 has a role in the toughness of bone and its resistance to fracture, suggesting new therapeutic targets. Read More

A genetic variant is associated with toxicity of the chemotherapy drug melphalan, and could guide individualized dosing for the medication. Read More

Having a “leaky” gut may protect against colitis, a paradoxical finding that alters understanding of the role of cell permeability in intestinal homeostasis and immune regulation. Read More

Patients who suffer a longer duration of delirium in the intensive care unit are more likely to experience long-term disability after discharge. Read More

A new mouse model reveals gene clusters important in a treatment-resistant form of leukemia. Read More