Leigh MacMillan
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Host proteins can control HIV infection
The protein APOBEC3G contributes to spontaneous control of HIV-1 in vivo and may provide therapeutic benefits. Read MoreOct 5, 2012
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Proteins help flip tumor’s invasive switch
Vanderbilt investigators have identified how two key components of cancer's invasive "switch" — the series of signaling events that turn on a tumor cell’s invasive behavior — work together. Read MoreOct 4, 2012
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Cell entry ports for cold virus
The respiratory virus HMPV uses its fusion (F) protein – which interacts with cellular receptors called integrins – to bind to and enter target cells. Read MoreSep 25, 2012
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How ‘Jedi’ disposes of dead neurons
The protein Syk is essential for clearing away neuron “corpses” in the developing peripheral nervous system. Read MoreSep 19, 2012
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Cells with LIP eat their neighbors
A transcription factor called LIP is capable of causing one cell to consume another. Read MoreSep 13, 2012
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New doctoral students welcomed
Vanderbilt University Medical Center welcomed 109 new doctoral students into the scientific community last week in the third annual “Simple Beginnings” ceremony. Read MoreSep 6, 2012
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Neuronal subtypes in genetic disorder
Inhibitory neurons that connect and regulate signaling in the brain (interneurons) may contribute to epilepsy and autism in patients with tuberous sclerosis complex. Read MoreSep 6, 2012
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Targeting new pathways to ease pain
The spinal cord’s neuropeptide Y signaling pathway may be a good target for new pain therapeutics. Read MoreAug 30, 2012
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Clues to retinal cell degeneration
A reversible chemical modification of rhodopsin, a receptor for light, plays a role in the degeneration of retinal cells. Read MoreAug 28, 2012
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VU, Lipscomb partner on dual degree program
A new cooperative program between Vanderbilt University and Lipscomb University’s College of Pharmacy is focusing on the next generation of pharmaceutical researchers. By offering a pathway for students to earn both Pharm.D. and Ph.D. degrees, the program aims to boost the number of pharmacy-trained research scientists. Read MoreAug 23, 2012
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Flu Tool guides patient decision-making
Studies of Flu Tool, a computer application that guides health care decision-making, suggests that patients are willing to use these types of resources. Read MoreAug 14, 2012
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New therapeutic target for cold, flu viruses identified
Viruses that cause acute respiratory infections — such as human metapneumovirus (HMPV) and flu — impair a set of immune system cells that should clear the virus from the lungs. Now, Vanderbilt University investigators have discovered the signaling pathway that disables these immune cells. Read MoreAug 9, 2012
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Team creates new view of body’s infection response
A new 3-D view of the body’s response to infection — and the ability to identify proteins involved in the response — could point to novel biomarkers and therapeutic agents for infectious diseases. Read MoreAug 9, 2012
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Ancestry impacts smoking risk for lungs
Smoking is more detrimental to lung function in individuals with high proportions of African ancestry. Read MoreAug 7, 2012
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On the hunt for bladder cancer factors
A protein linked to aggressive bladder cancers could point to new strategies for treatment or prevention. Read MoreJul 26, 2012
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Long antibodies better against HIV
Understanding how antibodies with long “loops” form may be important for HIV vaccine development. Read MoreJul 19, 2012
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VU study finds stress fuels breast cancer metastasis to bone
Stress can promote breast cancer cell colonization of bone, Vanderbilt Center for Bone Biology investigators have discovered. Read MoreJul 18, 2012
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Insights for neuroscience drug discovery
When discovering drugs for brain disorders, it’s important to test the candidates in multiple ways to avoid advancing those with restricted physiological effects. Read MoreJul 17, 2012
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Receptor’s role in nutrition brain circuitry
New findings point to brain circuitry that communicates about the body’s nutritional status and regulates how nutrients are mobilized. Read MoreJul 3, 2012
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Low oxygen could protect sick kidneys
Low oxygen – and the activation of factors that respond to this situation – may be protective in chronic kidney disease. Read MoreJun 28, 2012