Leigh MacMillan

One small chemical change to an existing antibacterial drug results in a compound that is more effective against its target enzyme in tuberculosis, Vanderbilt researchers have discovered. Read More

Vanderbilt researchers have developed a high-throughput assay that will aid in identifying new compounds to treat preterm labor or postpartum bleeding. Read More

Studies of the molecular complex that helps build specialized cellular surfaces could shed light on the mechanisms underlying a genetic deaf-blindness syndrome accompanied by intestinal disease. Read More

Emery Brown, M.D., Ph.D., a noted anesthesiologist, neuroscientist and statistician, will deliver the next Flexner Discovery Lecture on Thursday, Feb. 11. Read More

A family of proteins with critical roles in cell division, synaptic transmission and cell migration don’t all function the way scientists thought they did, according to two new studies led by Vanderbilt researchers. Read More

A microRNA — a small piece of RNA involved in regulating gene expression — functions as an oncogene to drive the development of lung cancer, Vanderbilt University investigators have discovered. Read More

The elasticity of a scaffold used for healing skin wounds is a key factor in promoting regeneration versus scarring. Read More

Roderick Little, Ph.D., a statistician with expertise in the analysis of data sets with missing values, will deliver the next Flexner Discovery Lecture on Thursday, Jan. 28. Read More

A team of Vanderbilt investigators developed a new method for rapidly generating heart muscle cells from stem cells. Read More

Vanderbilt investigators have identified a new biomarker to assess platelet function. Read More

Telomeres – the caps on the end of chromosomes – are a source of stress for a particular protein involved in copying DNA, a new study reports. Read More

Inducing “tolerance” to bacterial toxins in the endothelial cells that line blood vessels may offer a new approach for preventing the negative consequences of sepsis. Read More

Vanderbilt researchers have developed a new method to study cell signaling networks at single-cell resolution. Read More

Nancy Cox, Ph.D., founding director of the Vanderbilt Genetics Institute, will deliver the next Flexner Discovery Lecture on Thursday, Dec. 17. Read More

Microtubules — cellular “highways” that deliver cargo to the cell membrane for secretion — have a surprising role in pancreatic beta cells. Instead of facilitating glucose-stimulated insulin secretion, they limit it, a team of Vanderbilt investigators reported recently in Developmental Cell. Read More

Joe G.N. “Skip” Garcia, M.D., recognized for developing novel therapies for critically ill patients with acute inflammatory lung disease, will deliver the next Flexner Discovery Lecture on Thursday, Dec. 10. Read More

For her contributions to public communication, outreach and education about neuroscience, Nicole Baganz, Ph.D., a postdoctoral fellow in Pharmacology, received the 2015 Next Generation Award from the Society for Neuroscience. Read More

Vanderbilt investigators have generated a “parts list” for the molecular machinery that duplicates DNA each time a cell divides. The research has implications for cancer therapies that target components of this machinery. Read More

Understanding factors, such as the receptor TLR9, that detect and defend against pathogens may lead to therapeutic approaches that promote an effective immune response to treat infections. Read More

The timing of folic acid-containing prescription filling during pregnancy was associated with childhood asthma, according to a new Vanderbilt study. Read More