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pathology microbiology and immunology Archives

Pathology of septic shock

Feb. 8, 2017—The signaling molecule IL-15 promotes septic shock, a life-threatening condition involving organ injury caused by infection.

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Flu vaccine response in older adults

Jan. 25, 2017—High dose flu vaccine boosts the immune response in older adults by increasing activation of certain immune cells.

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Improving vaccine formulations

Jan. 20, 2017—The compound MPLA is an attractive vaccine component, designed to elicit a robust immune response.

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Metastatic pancreatic cancer ‘reprograms’ for malignancy

Jan. 19, 2017—Metastatic pancreatic cancer — cancer that has spread from the pancreas to other tissues and is responsible for most patient deaths — changes its metabolism and is “reprogrammed” for optimal malignancy, according to new findings reported Jan. 16 in Nature Genetics.

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Midgut neuroendocrine tumor prognosis

Jan. 6, 2017—Vanderbilt investigators recommend that the presence of tumor deposits in the abdomen be included when staging midgut neuroendocrine tumors.

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Single-cell analysis of solid tumors

Dec. 12, 2016—A new method will make it possible to study solid tumors and healthy tissues using mass cytometry.

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Targeting the “un-targetable”

Nov. 18, 2016—A novel drug that targets the protein RSK blocked aggressive breast cancers from metastasizing in an animal model.

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Sarcoidosis research, patient care focus of newly created center

Nov. 17, 2016—Vanderbilt University Medical Center (VUMC) has established a Sarcoidosis Center of Excellence under the direction of Wonder Drake, M.D., associate professor of Medicine and Pathology, Microbiology and Immunology.

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Stem cells promote tolerance

Nov. 17, 2016—Blood-forming stem cells play a role in immune tolerance and acceptance of organ transplants, Vanderbilt researchers have discovered.

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Links between immune cells and metabolism explored

Nov. 10, 2016—At the intersection of immunology and metabolism is a burgeoning new field: immunometabolism. It’s an area where Vanderbilt has exceptional strengths, said Jeffrey Rathmell, Ph.D., Cornelius Vanderbilt Professor of Immunobiology.

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Early study finds antibody that ‘neutralizes’ Zika virus

Nov. 7, 2016—Researchers at Vanderbilt University Medical Center and Washington University School of Medicine in St. Louis have isolated a human monoclonal antibody that in a mouse model “markedly reduced” infection by the Zika virus.

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VUMC investigators find pathogens work together to infect host

Nov. 3, 2016—Pseudomonas aeruginosa and Staphylococcus aureus — two pathogens that frequently co-infect the lungs of patients with cystic fibrosis — appear to cooperate with each other, Vanderbilt investigators have discovered. When pseudomonas is starved for metal by the host, it shuts down the production of factors that would normally kill staph, promoting a co-infection.

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