pathology microbiology and immunology Archives
RNA processing and antiviral immunity
Dec. 13, 2018—New research by John Karijolich and colleagues have found that RNA, not viruses, activate the sentry enzymes that serve as the first line of defense against viruses.
Discovery could lead to neutralizing West Nile virus
Dec. 7, 2018—Research led by James Crowe, Jr., could lead to the first effective treatment for this dangerous mosquito-transmitted infection.
Team’s findings show glutamine metabolism affects T cell signaling
Nov. 1, 2018—Jeffrey Rathmell and colleagues show that a drug that inhibits glutamine metabolism — currently in clinical trials as an anticancer agent — might also be useful as a treatment for inflammatory and autoimmune diseases.
Research reveals link between immunity, diabetes
Sep. 13, 2018—An immune cell called CD8+ is supposed to attack disease, but it can also contribute to inflammation, which can lead to insulin resistance and type 2 diabetes.
Team isolates antibodies that neutralize GI bug norovirus
Aug. 30, 2018—The discovery of these antibodies could significantly improve the diagnosis and treatment of the leading cause of stomach illness in the world.
Team finds potent antibodies against three Ebola viruses
Jul. 19, 2018—Researchers led by James Crowe Jr. are a step closer to developing a broadly effective antibody treatment against the three major Ebola viruses that cause lethal disease in humans. The hope is that the antibodies — like heat-seeking missiles — would seek out and destroy the viruses before they can wreak havoc in the body.
New staph virulence factor
Jun. 28, 2018—The new factor, an enzyme involved in host-pathogen interactions, may be a viable target for treating staph infections.
Karijolich named 2018 Pew Biomedical Scholar
Jun. 14, 2018—John Karijolich, PhD, assistant professor of Pathology, Microbiology, and Immunology at Vanderbilt University Medical Center, has been named a Pew Biomedical Scholar by The Pew Charitable Trusts.
A “public” target for HIV
Jun. 8, 2018—Common sequences of antibodies against HIV may be key to developing a successful vaccine strategy for the virus.
New target to stop Ebola
May. 21, 2018—A new Vanderbilt study suggests it may be possible to develop antibody therapies or a universal vaccine effective against multiple Ebola virus family members.
Alphavirus “Achilles heel”
May. 17, 2018—Targeting the protein that mosquito-borne viruses use to enter cells could be a strategy for preventing infection by multiple emerging viruses.
Study finds acetaminophen helps reduce acute kidney injury risk in children following cardiac surgery
May. 14, 2018—Children who underwent cardiac surgery were less likely to develop acute kidney injury if they had been treated with acetaminophen in the first 48 hours after their procedures, according to a Vanderbilt study just published in JAMA Pediatrics.