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Researchers at Vanderbilt University Medical Center (VUMC) are leading a multicenter clinical trial to evaluate whether a shorter course of antibiotics — five days instead of 10 — is effective at treating community-acquired pneumonia (CAP) in children who show improvement after the first few days of taking antibiotics. Read More

In a new study, Vanderbilt pharmacologist Jerod Denton, Ph.D., Ohio State entomologist Peter Piermarini, Ph.D., and colleagues report an experimental molecule that inhibits kidney function in mosquitoes and thus might provide a new way to control the deadliest animal on Earth. Read More

Vanderbilt investigators have discovered how antidepressant medicines that block serotonin uptake can increase bleeding risk. Read More

Vanderbilt researchers have discovered steps in the regulation of a key enzyme that builds the basement membrane, a structure that undergirds nearly all animal tissues. Read More

A novel drug that targets the protein RSK blocked aggressive breast cancers from metastasizing in an animal model. Read More

Blood-forming stem cells play a role in immune tolerance and acceptance of organ transplants, Vanderbilt researchers have discovered. Read More

Understanding how mutations affect the structure and function of inhibitory neurotransmitter receptors will shed light on the mechanisms underlying some types of epilepsy. Read More

Vanderbilt researchers have shown that an injectable material improves wound healing and may be useful for large skin wounds such as those in patients with diabetes. Read More

Researchers at Vanderbilt University Medical Center and Washington University School of Medicine in St. Louis have isolated a human monoclonal antibody that in a mouse model “markedly reduced” infection by the Zika virus. Read More

Pseudomonas aeruginosa and Staphylococcus aureus — two pathogens that frequently co-infect the lungs of patients with cystic fibrosis — appear to cooperate with each other, Vanderbilt investigators have discovered. When pseudomonas is starved for metal by the host, it shuts down the production of factors that would normally kill staph, promoting a co-infection. Read More

Vanderbilt researchers have discovered a link between Helicobacter pylori infection, inflammation and gastric cancer that could suggest new anti-cancer therapies. Read More

Specific interactions between inflammatory cells and epithelial cells contribute to lung fibrosis, according to a study published last week in JCI Insight fromVanderbilt’s Lisa Young, M.D., associate professor of Pediatrics and Medicine and Cell and Developmental Biology, and colleagues. Read More

A team of Vanderbilt scientists have genetically modified luciferase, the enzyme that produces bioluminescence, so that it acts as an optical sensor that records activity in brain cells. Read More

At Vanderbilt University Medical Center (VUMC) there are about 486 distinct operational units involved in inpatient care and evaluation. Read More

A new method for analyzing cells in fixed biopsy tissues from patients by guide personalized treatment strategies for cancer. Read More

Lengthening sleep duration and reducing sleep disturbances in children with type 1 diabetes may improve diabetes outcomes and reduce parental stress. Read More

Vanderbilt researchers have determined that a previously uncharacterized protein responds to DNA replication stress and has an essential role in maintaining the integrity of the genome. Read More

To prepare for the potential of a smallpox return, Vanderbilt researchers are isolating and studying naturally occurring antibodies from the blood of previously infected or immunized people. Read More

A compound found in buckwheat seeds extends the lifespan of worms, Vanderbilt investigators have discovered. Read More

Respiratory syncytial virus (RSV) is the major cause of life-threatening viral pneumonia in infants worldwide, yet despite repeated efforts, scientists have been unable to develop an effective vaccine against it. Read More