NIH

A team of Vanderbilt investigators has pinpointed the role of bile acids and a specific signaling pathway in the positive metabolic effects of weight-loss surgery. Read More

New research led by Rebecca Cook demonstrates that an antiviral receptor called RIG-I has potent immunogenic and therapeutic effects in breast cancer. Read More

Mukhtar Ahmed and colleagues say the methods they employed to understand the mechanisms by which exocysts--protein complexes essential to life--function have the potential to revolutionize our understanding of cell dynamics. Read More

The report authored by Margaret Adgent adds to the increasing evidence supporting the reproductive health consequences of early-life exposure to soy formula. Read More

Research led by James Crowe, Jr., could lead to the first effective treatment for this dangerous mosquito-transmitted infection. Read More

A complete map of gene expression for the worm may help address broad questions in neuroscience about how gene expression programs establish diverse sets of neurons and how genetic differences contribute to neuronal function in healthy and disease conditions. Read More

Research led by Billy Hudson has identified an antibody associated with pulmonary-renal syndrome, a rare autoimmune condition. Read More

Vanderbilt will conduct a clinical trial of an intervention for young children with language delays in an NIDCD study. Read More

A recent study led by Xiao-Ou Shu and colleagues found that green tea drinking was associated with increased risk of type 2 diabetes in Chinese adults, possibly due to the use of pesticides on tea plants--though the researchers call for further study of the exact mechanism. Read More

Qi Liu, PhD, Ken Lau, PhD, and colleagues have developed a new tool, sc-UniFrac, to quantify diverse cell types in single-cell studies. Read More

People with diabetes may be prone to more skin infections due to an overabundance of a compound that controls inflammation in the body. Read More

In the first large-scale analysis of cardiovascular complications linked to immune checkpoint inhibitors, Vanderbilt researchers have identified several of the conditions that arise and have determined that they usually appear early in treatment. Read More

Jeffrey Rathmell and colleagues show that a drug that inhibits glutamine metabolism — currently in clinical trials as an anticancer agent — might also be useful as a treatment for inflammatory and autoimmune diseases. Read More

This work was the foundation for an NSF grant to interrogate how the Rif1 protein controls DNA replication. Read More

James Patton and colleagues have demonstrated how colon cancer cells transmit genetic data to other cells. Read More

A new link between a support protein within the brain's white matter and known Alzheimer's biomarkers discovered by Angela Jefferson and colleagues bring researchers a step toward earlier and more precise detection of neuropathology underlying cognitive impairment that may lead to new targeted therapies Read More

Raymond Harris, Ming-Zhi Zhang and colleagues suggest pathways activated by the epidermal growth factor receptor may be promising targets for treating diabetic kidney disease. Read More

New findings by Dawn Newcomb and colleagues suggest an explanation for why women are more prone to asthma than men. Read More

Research led by Sanjay Mishra, and colleagues suggests modular sHSP architecture contributes to the ability of heat-protective proteins to serve as chaperones for a range of unfolded proteins. Read More

Loss of a protein that regulates mitochondrial function can greatly increase the risk of a heart attack, report Eric Gamazon, Sandra Zinkel and graduate students Christie Salisbury-Ruf and Clinton Bertram in new research. Read More