NIH
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New biomaterial could improve bone grafting
A new biomaterial-based bone graft extender created by Vanderbilt and U.S. Army researchers has the potential to improve treatment of critical orthopedic conditions. Read MoreFeb 26, 2019
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Skin diseases study uses crowdsourcing to gather data
Identifying and quantifying skin lesions often requires hours of tedious visual inspection by experts, making it difficult to study a lot of them at once. Eric Tkaczyk and Daniel Fabbri have found that training multiple non-experts to do basic evaluations can achieve comparable results. Read MoreFeb 21, 2019
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Discovery of new “checkpoint” points to new cancer immunotherapy option
An international team involving Vanderbilt researchers has discovered that a new “checkpoint” protein on immune system cells is active in tumors, and that blocking it — in combination with other treatments — is a successful therapeutic approach in mouse models of cancer. Read MoreFeb 21, 2019
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Adhesion protein optimizes border
Matthew Tyska and colleagues have found that an adhesion protein in the gut is necessary for proper intestinal functioning. Read MoreFeb 15, 2019
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Modulating stress circuits
Danny Winder and colleagues have demonstrated how norepinephrine and a stress factor call CRF interact, which may lead to new treatments for stress-related disorders. Read MoreFeb 15, 2019
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Probing H. pylori cancer protein
Timothy Cover, john Loh and colleagues have identified how a certain type of mutation influences the risk of premalignant and malignant changes in the stomach. Read MoreFeb 15, 2019
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Reversing stress-related anxiety
Inhibiting COX-2 — an enzyme associated with inflammation — could provide a novel therapeutic approach for stress-related psychiatric disorders. Read MoreFeb 14, 2019
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Faculty may apply for 2019 NIH S10 Shared and High-end Instrumentation Grants
The NIH has now posted information for the 2019 S10 Shared and High-end Instrumentation Grants programs. Read MoreFeb 8, 2019
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New target for chronic kidney disease
Craig Brooks and colleagues have identified a mechanism of kidney fibrosis progression, suggesting a potential new angle for treating chronic kidney disease. Read MoreJan 31, 2019
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Destructive ‘telegrams’ in asthma
Heather Pua and colleagues have identified the source of cellular signals that may play a role in triggering an asthma attack. Read MoreJan 31, 2019
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Study finds unique form of chronic sinusitis in older patients
Older patients with a diagnosis of chronic sinusitis have a unique inflammatory signature that may render them less responsive to steroid treatment, according to new research led by Justin Turner. Read MoreJan 18, 2019
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DNA’s on/off switch
Walter Chazin and colleagues have identified how a chemical "switch" in DNA primase, an enzyme essential to the replication of our genomes, works in order to hand off genetic information to the next enzyme. Read MoreJan 18, 2019
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Signals from the “conveyor belt”
Carlos Lopez, Tina Iverson and Vsevolod Gurevich propose that a conveyer belt best describes the mechanism by which cellular signals are handed off from enzyme to enzyme in the brain. Read MoreJan 18, 2019
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Building a pancreas
Ken Lau and Guoqiang Gu have identified a critical biomarker in determining how a pancreatic progenitor cell will develop. Read MoreJan 17, 2019
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Research explores link between stem cell transplant, diabetes
Brian Engelhardt is studying why as many as 50 percent of stem cell transplant recipients develop diabetes. Read MoreJan 17, 2019
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Pain relievers a risk for C. diff?
David Aronoff and colleagues report an increased risk of the serious gastrointestinal infection C. diff following the use of NSAID pain relievers. Read MoreJan 17, 2019
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Trans-institutional team documents potential new treatment path for breast cancer
A team led by biomolecular engineer John Wilson and cancer biologist Rebecca Cook have found a way to trigger an immune response that targets breast cancer cells. Read MoreJan 16, 2019
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Bile acids mediate metabolic benefits of weight-loss surgery
A team of Vanderbilt investigators has pinpointed the role of bile acids and a specific signaling pathway in the positive metabolic effects of weight-loss surgery. Read MoreJan 10, 2019
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Breast cancer-killing RIG
New research led by Rebecca Cook demonstrates that an antiviral receptor called RIG-I has potent immunogenic and therapeutic effects in breast cancer. Read MoreDec 19, 2018
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The exocyst dynamo
Mukhtar Ahmed and colleagues say the methods they employed to understand the mechanisms by which exocysts--protein complexes essential to life--function have the potential to revolutionize our understanding of cell dynamics. Read MoreDec 14, 2018