NCI

David Cortez and colleagues have discovered a new DNA repair mechanism. Read More

An international team involving Vanderbilt researchers has discovered that a new “checkpoint” protein on immune system cells is active in tumors, and that blocking it — in combination with other treatments — is a successful therapeutic approach in mouse models of cancer. Read More

Timothy Cover, john Loh and colleagues have identified how a certain type of mutation influences the risk of premalignant and malignant changes in the stomach. Read More

Ken Lau and Guoqiang Gu have identified a critical biomarker in determining how a pancreatic progenitor cell will develop. Read More

New research led by Rebecca Cook demonstrates that an antiviral receptor called RIG-I has potent immunogenic and therapeutic effects in breast cancer. Read More

A recent study led by Xiao-Ou Shu and colleagues found that green tea drinking was associated with increased risk of type 2 diabetes in Chinese adults, possibly due to the use of pesticides on tea plants--though the researchers call for further study of the exact mechanism. Read More

Qi Liu, PhD, Ken Lau, PhD, and colleagues have developed a new tool, sc-UniFrac, to quantify diverse cell types in single-cell studies. Read More

In the first large-scale analysis of cardiovascular complications linked to immune checkpoint inhibitors, Vanderbilt researchers have identified several of the conditions that arise and have determined that they usually appear early in treatment. Read More

Jeffrey Rathmell and colleagues show that a drug that inhibits glutamine metabolism — currently in clinical trials as an anticancer agent — might also be useful as a treatment for inflammatory and autoimmune diseases. Read More

James Patton and colleagues have demonstrated how colon cancer cells transmit genetic data to other cells. Read More

A new study by Harvey Murff finds that diabetics who take metformin have lower rates of liver cancer than those who take other diabetes drugs. Read More

Stephen Deppen and colleagues have developed an updated map showing new areas of increased risk for a common lung infection. Read More

Researchers led by melanoma researcher Douglas Johnson have answered questions about the incidence and timing of rare but sometimes fatal reactions to the most widely prescribed class of immunotherapies. Read More

Vanderbilt researchers describe how certain tuberculosis treatments work and suggest these medications may overcome the threat of drug-resistant tuberculosis. Read More

A special genetic analysis has revealed candidate genes associated with increased risk of breast cancer. Read More

The bacterium H. pylori is a leading cause of stomach cancer, and Vanderbilt researchers are studying how one of its toxins gets into cells. Read More

New research links nutrient-responsive cellular signaling to the antibody-mediated immune response. Read More

Treatments for common skin conditions such as atopic dermatitis may be improved by understanding the enzymes responsible for forming the skin’s water-tight barrier. Read More

Vanderbilt investigators have discovered that cancer treatment induces an “idling” state for cells, which could promote resistance to treatment. Read More

New findings suggest that oxidative stress damages mitochondrial DNA, and they link this damage to a disease state. Read More