• colonoscopy endoscope

    Better adenoma detection

    Fluorescent nanoparticles clearly identified colonic adenomas — precursors to colorectal cancer — in mice, and the formulation should translate to clinical use in humans. Read More

    May 4, 2023

  • RNA molecule illustration

    Study details RNA editing in virus-infected cancer cells

    Vanderbilt researchers detail the landscape of RNA editing — a form of RNA modification — in primary effusion lymphoma cells during Kaposi’s sarcoma-associated herpesvirus infection and identify an edited viral microRNA that is critical for infection. Read More

    Apr 20, 2023

  • e coli

    Study describes how E. coli co-opts cells, causes recurrent UTIs

    Researchers at Vanderbilt University Medical Center have discovered why the uropathogenic bacterium E. coli, the leading cause of urinary tract infections, is so tenacious; their findings could lead to new ways to prevent recurrent UTIs. Read More

    Aug 25, 2022

  • Chemical element symbol for zinc from the periodic table

    Study identifies first cellular “chaperone” for zinc, sheds light on worldwide public health problem of zinc deficiency

    A team led by Vanderbilt researchers has described and characterized the first zinc metallochaperone: a protein that puts zinc into other “client” proteins. Read More

    May 17, 2022

  • a table spread with a wide variety of furits and vegetables

    Diet and colorectal cancer risk

    Higher dietary intake of antioxidant compounds found in fruits, vegetables, teas and spices was associated with lower risk of colorectal cancer, and intake was lower among Black participants, potentially contributing to colorectal cancer health disparities. Read More

    Feb 14, 2022

  • Vanderbilt University

    Impaired neutrophils in autoimmunity

    Vanderbilt researchers help answer the question of why patients with autoimmune diseases like lupus are more susceptible to bacterial infections: their neutrophils have impaired antibacterial activity. Read More

    Jan 27, 2022

  • Helicobacter Pylori bacterium, medical illustration pathogenic microorganism in human stomach

    H. pylori, lipid loss and stomach cancer

    H. pylori infection — a strong risk factor for stomach cancer — changes the composition of stomach lipids, which could offer new biomarkers for detecting premalignant changes, Vanderbilt researchers discovered. Read More

    Jan 17, 2022

  • Vanderbilt University

    Salmonella overcomes host resistance

    The invading pathogen Salmonella, a common cause of food poisoning, can change its metabolism to overcome host resistance to its colonization. Read More

    Jan 13, 2022

  • Vanderbilt University

    Oral microbes and gastric cancer

    Studies in three large population cohorts that include Asian, African American and European American people support a role for the oral microbiota — the collection of microbial species in the mouth — in gastric cancer development. Read More

    Dec 13, 2021

  • Vanderbilt University

    Prostate cancer treatment regret

    Vanderbilt researchers suggest that to reduce treatment-related regret for men with localized prostate cancer, treatment preparation should focus on shared decision-making and aligning patient expectations with treatment toxicity. Read More

    Dec 9, 2021

  • Dividing cancer cell illustration

    The role of polarity in early cancer

    Mutations in the protein epiregulin, an EGF receptor ligand, affect larger epithelial cell reorganization and may contribute to early cancer development, Vanderbilt researchers discovered. Read More

    Sep 21, 2021

  • African American woman in pink crossing her hands over her breast

    Structural variants in breast cancer risk genes

    Vanderbilt epidemiologists conducted in-depth whole genome sequencing of breast cancer risk genes in Black women, who die at higher rates and have more aggressive disease, to discover mutations that may improve testing and treatment selection. Read More

    Sep 16, 2021

  • A Korean woman with cancer is meeting with her doctor. Chemotherapy treatment is going well. The patient is smiling at her doctor as he shares with her positive news. (A Korean woman with cancer is meeting with her doctor. Chemotherapy treatment is go

    Prediction models for breast cancer

    Vanderbilt researchers developed new prognostic models for breast cancer outcomes and found that adding postdiagnostic weight change as a factor improves the prediction. Read More

    Jul 27, 2021

  • Concept of DNA molecule composed of computer imagery like numbers

    Researchers discover that protein switches functions to regulate DNA replication

    Vanderbilt biochemists have discovered that the protein RADX has different biological effects at sites of DNA synthesis, depending on the cellular conditions — even though it works the same way in both stressed and unstressed cells. Read More

    Jul 22, 2021

  • doctor checking patient's blood pressure

    Genetic ancestry and hypertension risk

    Racial disparities in hypertension risk are due in part to genetic differences between ancestries, Vanderbilt investigators find in a study of participants in the Million Veteran Program. Read More

    Apr 29, 2021

  • Vanderbilt University

    New therapeutic strategy for leukemia syndrome

    Using primary cells from patients with chronic myelomonocytic leukemia, Vanderbilt researchers found synergistic inhibition of cell viability and proliferation, suggesting a new treatment strategy. Read More

    Apr 20, 2021

  • Vanderbilt University

    Study revises understanding of cancer metabolism

    Tumors consume glucose at high rates, but a team of Vanderbilt researchers has discovered that cancer cells themselves are not the culprit, upending models of cancer metabolism that have been developed and refined over the last 100 years. Read More

    Apr 7, 2021

  • man checkup doctor hospital

    Prostate cancer microenvironment

    Distinct cancer-associated fibroblasts in the prostate tumor microenvironment may influence tumor progression and could point to new therapeutic targets. Read More

    Mar 23, 2021

  • Vanderbilt University

    Probiotic protection

    A probiotic factor given early in life to mice prevented intestinal inflammation in adulthood, providing a rationale for probiotic intervention in individuals at high risk of developing inflammatory bowel disease. Read More

    Mar 4, 2021

  • Vanderbilt University

    Gene network for leukemia factor

    A new method speeds the analysis of factors that control gene expression from days to minutes, allowing researchers to uncover new targets for cancer treatment. Read More

    Feb 4, 2021