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NCI

Pathways of radiosensitization

Apr. 12, 2019—Austin Kirschner and colleagues are learning more about how the cancer drug enzalutamide combines with radiation therapy to treat difficult prostate tumors.

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Cancer’s SOS

Apr. 4, 2019—Stephen Fesik and colleagues have uncovered more details about how a crucial component of RAS proteins, which trigger about a third of all tumors, work. This finding will help advance the discovery of new cancer therapies.

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Cancer prevention drug also disables H. pylori bacterium

Mar. 28, 2019—A medicine currently being tested as a chemoprevention agent for multiple types of cancer has more than one trick in its bag when it comes to preventing stomach cancer, Vanderbilt researchers have discovered.

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Novel DNA repair mechanism preserves genome integrity: study

Feb. 28, 2019—David Cortez and colleagues have discovered a new DNA repair mechanism.

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Discovery of new “checkpoint” points to new cancer immunotherapy option

Feb. 21, 2019—An international team involving Vanderbilt researchers has discovered that a new “checkpoint” protein on immune system cells is active in tumors, and that blocking it — in combination with other treatments — is a successful therapeutic approach in mouse models of cancer.

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Probing H. pylori cancer protein

Feb. 15, 2019—Timothy Cover, john Loh and colleagues have identified how a certain type of mutation influences the risk of premalignant and malignant changes in the stomach.

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Building a pancreas

Jan. 17, 2019—Ken Lau and Guoqiang Gu have identified a critical biomarker in determining how a pancreatic progenitor cell will develop.

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Breast cancer-killing RIG

Dec. 19, 2018—New research led by Rebecca Cook demonstrates that an antiviral receptor called RIG-I has potent immunogenic and therapeutic effects in breast cancer.

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Green tea and diabetes

Nov. 30, 2018—A recent study led by Xiao-Ou Shu and colleagues found that green tea drinking was associated with increased risk of type 2 diabetes in Chinese adults, possibly due to the use of pesticides on tea plants--though the researchers call for further study of the exact mechanism.

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Analyzing single-cell landscapes

Nov. 30, 2018—Qi Liu, PhD, Ken Lau, PhD, and colleagues have developed a new tool, sc-UniFrac, to quantify diverse cell types in single-cell studies.

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Immunotherapies linked to specific heart complications

Nov. 16, 2018—In the first large-scale analysis of cardiovascular complications linked to immune checkpoint inhibitors, Vanderbilt researchers have identified several of the conditions that arise and have determined that they usually appear early in treatment.

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Team’s findings show glutamine metabolism affects T cell signaling

Nov. 1, 2018—Jeffrey Rathmell and colleagues show that a drug that inhibits glutamine metabolism — currently in clinical trials as an anticancer agent — might also be useful as a treatment for inflammatory and autoimmune diseases.

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