Martin Egli
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Vanderbilt biochemists discover breakthrough evolution-resistant compound to combat antibiotic resistance
Vanderbilt scientist Houra Merrikh led a team of researchers who discovered the first evolution-resistant chemical compound that prevents drug resistance development in bacteria. The compound is also a drug development platform that targets antimicrobial resistance during treatment of infections with antibiotics and evolution in general, Merrikh said. Read MoreMar 1, 2024
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Vanderbilt biochemists discover breakthrough anti-evolution compound to combat antibiotic resistance
The World Health Organization ranks antimicrobial resistance as one of the top ten global health risks. Vanderbilt researchers led by Houra Merrikh identified the first anti-evolution compound that targets AMR during treatment of infections with antibiotics. Read MoreFeb 26, 2024
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Biochemist Martin Egli elected to the European Academy of Sciences and Arts
For his outstanding achievements, including investigations directed at nucleic acid structure, DNA bypass polymerases and the circadian clock, Martin Egli has been elected to the European Academy of Sciences and Arts. The academy is dedicated to innovative research, interdisciplinary and transnational collaboration. Read MoreOct 25, 2023
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Grant enhances study of new chemotherapy targets
Vanderbilt chemists have been awarded $7.2 million over the next five years from the National Cancer Institute to lead an initiative to better understand how a combination chemotherapy for breast cancer targets DNA. Read MoreOct 19, 2018
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Altered metabolism and disease
Vanderbilt researchers report a structure of a human metabolic enzyme bound to its substrate 17alpha-hydroxyprogesterone. Read MoreJul 25, 2017
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Faulty building blocks in DNA
An enzyme that builds DNA is able to insert the wrong building blocks, which could generate mutations. Read MoreJan 22, 2016
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Bypassing DNA damage
Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage. Read MoreMay 9, 2014
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Carcinogenic chemicals cramp DNA
Researchers have determined how a DNA lesion caused by exposure to chemicals may spark cancer formation. Read MoreNov 21, 2012
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DNA: From modification to mutation
Understanding how an environmental hazard damages DNA may shed light on processes of tumor formation. Read MoreJun 8, 2012
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Fungus toxin gets in the way in DNA
Structural studies are providing insight to how aflatoxin – a toxin produced by fungi – contributes to cancer development. Read MoreOct 7, 2011
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Fluorine aids gene silencing
Modifying a form of RNAs may improve their efficacy for research and medical uses. Read MoreFeb 15, 2011