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James Crowe

Flu’s “hidden target” may lead to universal vaccine: study

May. 16, 2019—The flu mutates so quickly that we need a new vaccine every year, but Vanderbilt scientists have found a vulnerable part of the virus that doesn't mutate as much.

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VUMC chikungunya antibody set to enter clinical trial

Feb. 21, 2019—A monoclonal antibody against the chikungunya virus developed by researchers at Vanderbilt University Medical Center is the first monoclonal antibody encoded by messenger RNA to enter a clinical trial.

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Researchers push forward frontiers of vaccine science

Feb. 13, 2019—Using sophisticated gene sequencing and computing techniques, Vanderbilt researchers have achieved a first-of-its-kind glimpse into how the body’s immune system gears up to fight off infection.

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Designing antibodies to fight the flu

Jan. 31, 2019—James Crowe Jr. and colleagues have developed a new computational method that may allow researchers to develop flu antibodies that can protect against more strains of the disease.

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VUMC scientists ‘sprint’ to find anti-Zika antibodies

Jan. 25, 2019—Scientists at Vanderbilt University Medical Center and colleagues in Boston, Seattle and St. Louis are racing to develop — in a mere 90 days — a protective antibody-based treatment that can stop the spread of the Zika virus.

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Research explores link between stem cell transplant, diabetes

Jan. 17, 2019—Brian Engelhardt is studying why as many as 50 percent of stem cell transplant recipients develop diabetes.

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Discovery could lead to neutralizing West Nile virus

Dec. 7, 2018—Research led by James Crowe, Jr., could lead to the first effective treatment for this dangerous mosquito-transmitted infection.

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Team isolates antibodies that neutralize GI bug norovirus

Aug. 30, 2018—The discovery of these antibodies could significantly improve the diagnosis and treatment of the leading cause of stomach illness in the world.

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New target to stop Ebola

May. 21, 2018—A new Vanderbilt study suggests it may be possible to develop antibody therapies or a universal vaccine effective against multiple Ebola virus family members.

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Alphavirus “Achilles heel”

May. 17, 2018—Targeting the protein that mosquito-borne viruses use to enter cells could be a strategy for preventing infection by multiple emerging viruses.

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Hope for an RSV vaccine

Feb. 23, 2018—Newly discovered features in an RSV protein may be useful for rational structure-based vaccine design.

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Flu Fighter: Dr. James Crowe is leading a global effort to take the guesswork out of the flu shot

Feb. 6, 2018—From Vanderbilt Magazine: James Crowe, director of the Vanderbilt Vaccine Center, hopes to create a universal flu vaccine--permanently eliminating the problem of ineffective or under-effective annual flu shots.

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