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For more than a decade Matt Lang and collaborators across the U.S. have worked to recreate key components of T-cells and how they know when to start fighting disease. Conventional wisdom suggested that T-cells formed regular, force-free bonds with infected cells, and in doing so caused the chain reaction of immune response. The team slowly... Read More

A new, $8.7 million project—Design. R–AI-assisted CPS Design—involves pathbreaking work for the Defense Advanced Research Projects Agency as future cyber-physical systems will rely less on human control and more machine learning algorithms and artificial intelligence processors. Read More

Vanderbilt researchers awarded one of NSF’s 24 new projects to drive future manufacturing One of the challenges of drug delivery systems is to optimize their targeting properties so therapeutic compounds used in smaller amounts reach only a specific area of the body and result in little or no side effects. The ability to engineer the... Read More

Specific regions of the thalamus — a central brain region — are smaller in adults with psychotic disorders and youth at risk for psychotic disorders and are associated with cognitive impairment. Read More

Studies using large DNA biobanks revealed genetic variants associated with penicillin allergy, the most common type of drug-induced allergic reaction. Read More

Cody Siciliano, PhD, assistant professor of Pharmacology in the Vanderbilt University School of Medicine, has been selected to receive a one-year, $100,000 research award from the Stanley Cohen Innovation Fund to support his studies of the neural substrates of memory. Read More

Understanding immunity generated by smallpox vaccine may hold lessons for COVID-19 vaccine development. Read More

What users mention in online weight loss forum tracks with how much weight they lose. Read More

Researchers at Vanderbilt University Medical Center have identified antibodies that, in animals, block infection by alphaviruses, which can cause chronic and debilitating joint pain and arthritis and are an increasing global health concern. Read More

Vanderbilt University Medical Center has been awarded a one-year, $34-million grant by the National Center for Advancing Translational Sciences, part of the National Institutes of Health, to conduct a nationwide study of “convalescent plasma” as a treatment for COVID-19. Read More

A small-molecule “scavenger” that reduces inflammation and formation of atherosclerotic plaque in blood vessels in mice potentially could lead to a new approach for treating atherosclerosis in humans, according to researchers at Vanderbilt University Medical Center. Read More

Understanding how bacteria evolve resistance to antibiotics and host stresses could guide the development of more effective antimicrobial therapeutics. Read More

An international group of researchers including Vanderbilt epidemiologists has identified new DNA methylation biomarkers associated with prostate cancer risk. Read More

The transcriptional coregulator Swi-independent 3 — or Sin3 — switches on and off the genes that drive crucial biological processes during prenatal development, including cellular differentiation, maturation, survival, metabolism, and stress responses. Read More

When a bouncy ball deforms under the weight of your body, its rubber membrane stretches and contracts. Likewise, the membrane of a cell doubling itself prior to division must accommodate changes in intracellular pressure — or explode. Read More

RNA viruses invade cells and co-opt cellular machinery to replicate and translate their genomic material. Read More

The oncogene MYCN regulates cancer cell growth, proliferation, metabolism, and survival; tumors with increased MYCN expression are more aggressive. Read More

Eric Gamazon, PhD, assistant professor of Medicine, has been awarded a $1.5 million grant from the National Human Genome Research Institute, part of the National Institutes of Health (NIH), to develop novel computational tools that integrate functional genomic data and electronic health records. Read More

Angela Jefferson, PhD, professor of Neurology and director of the Vanderbilt Memory and Alzheimer’s Center, has been awarded a $3.7 million, three-year grant from the National Institute on Aging (NIA) to support establishment of a prospective NIA-funded Alzheimer’s Disease Research Center (ADRC) at Vanderbilt University Medical Center. Read More

Women with three or more uterine fibroids — non-cancerous growths — during pregnancy are more likely to have infants with reduced birthweight and may need additional surveillance. Read More