Health And Medicine
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Study of fully vaccinated patients with cancer who had breakthrough COVID-19 shows 13% mortality rate
New research finds that fully vaccinated patients with cancer who had breakthrough COVID-19 infections remained at high risk for hospitalization and death. Read MoreDec 24, 2021
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Study finds pixaban (Eliquis) is preferable to rivaroxaban (Xarelto) for stroke prevention, reduced bleeding complications
There is strong evidence that the medication apixaban (Eliquis) is preferable to rivaroxaban (Xarelto) for stoke prevention in patients with atrial fibrillation (AF), with both reduced rates of severe bleeding complications as well as strokes, according to study published Dec. 21 in JAMA. Read MoreDec 21, 2021
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“Atlas” of lung development may aid efforts to heal premature lungs
Researchers at Vanderbilt University Medical Center have constructed a single-cell “atlas” of lung development that tracks multiple cell types over time. Read MoreDec 20, 2021
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Study finds similar success rates with two devices for breathing tube placement
Two devices for placing a breathing tube during critical illness had similar success rates for intubation on the first attempt, according to a study published Dec. 8 in JAMA. Read MoreDec 15, 2021
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Immune landscape in adrenal cancer
The profile of immune-related gene expression and tumor-infiltrating immune cells in adrenocortical cancer suggests targets for new treatment strategies. Read MoreDec 14, 2021
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Oral microbes and gastric cancer
Studies in three large population cohorts that include Asian, African American and European American people support a role for the oral microbiota — the collection of microbial species in the mouth — in gastric cancer development. Read MoreDec 13, 2021
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“Supermeres” may carry clues to cancer, Alzheimer’s disease and COVID-19
Vanderbilt researchers have discovered a nanoparticle released from cells, called a “supermere,” which contains enzymes, proteins and RNA associated with multiple cancers, cardiovascular disease, Alzheimer’s disease and even COVID-19. Read MoreDec 10, 2021
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Cell signaling targets in leukemia
Vanderbilt researchers identified a critical role for IL-1beta signaling in leukemia cells with a certain mutation, suggesting this pathway may be a good target for novel treatments. Read MoreDec 9, 2021
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Prostate cancer treatment regret
Vanderbilt researchers suggest that to reduce treatment-related regret for men with localized prostate cancer, treatment preparation should focus on shared decision-making and aligning patient expectations with treatment toxicity. Read MoreDec 9, 2021
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International study supports dupilumab for treatment of moderate-to-severe asthma in children
In a late-stage clinical trial, the biologic agent dupilumab reduced the rate of severe asthma attacks and improved lung function and asthma control for children ages 6 to 11 with moderate-to-severe asthma, offering a new option to these patients. Read MoreDec 8, 2021
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Gene discoveries give new hope to people who stutter
New research shows the potential to identify therapeutic directions that could improve outcomes for people who stutter. Read MoreDec 2, 2021
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Thyroid cancer paper lands national recognition
Researchers in the Endocrine Neoplasia Research Laboratory at Vanderbilt University Medical Center have received national recognition for their work to discover better treatments for thyroid cancer. A paper describing their lab work was awarded first place in the Basic Science category at the 2021 Cancer Research Competition. Read MoreDec 2, 2021
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Study links depression scores, white blood cell count
Researchers across four health care systems, including Vanderbilt University Medical Center, have found that increased depression polygenic scores are associated with increased white blood cell count, highlighting the importance of the immune system in the etiology of depression. Read MoreDec 2, 2021
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Study provides new insight into how antidepressant drugs work
A study by Vanderbilt researchers sheds light on how current antidepressant drugs work and suggests a new drug target in depression. Read MoreDec 1, 2021
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‘Multi-omics’ reveals treatment option for breast cancer subtype
by Bill Snyder In a multidisciplinary collaboration, researchers at Vanderbilt University Medical Center and the University of Miami Miller School of Medicine have identified a subtype of triple-negative breast cancer (TNBC) that appears to be able to escape detection by the immune system and evade immunotherapy. Their report, published Nov. 1 in the journal... Read MoreNov 18, 2021
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AI predicts 24-hour hospital discharge
Vanderbilt researchers used a machine learning algorithm and data from more than 26,000 hospital stays to predict who would and would not be discharged over the next 24 hours. Read MoreNov 16, 2021
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CRISPR screen identifies new anti-inflammatory drug target
A novel CRISPR screen developed by Vanderbilt researchers identified a promising new target for anti-inflammatory therapeutics. Read MoreNov 11, 2021
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The power of white matter
Using a novel analysis of fMRI data, Vanderbilt researchers discovered intriguing patterns of signals in the brain’s white matter, the “conduit” for relaying signals between different brain regions. Read MoreNov 11, 2021
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“Ultra-potent” antibody against COVID-19 variants isolated at VUMC
A technology developed at Vanderbilt has led to the discovery of an “ultra-potent” monoclonal antibody against multiple variants of SARS-CoV-2, the virus responsible for COVID-19, including the delta variant. Read MoreSep 22, 2021
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The role of polarity in early cancer
Mutations in the protein epiregulin, an EGF receptor ligand, affect larger epithelial cell reorganization and may contribute to early cancer development, Vanderbilt researchers discovered. Read MoreSep 21, 2021