DNA Repair

Vanderbilt biochemists have discovered that the protein RADX has different biological effects at sites of DNA synthesis, depending on the cellular conditions — even though it works the same way in both stressed and unstressed cells. Read More

An indirect comparative effectiveness study using published data suggests that the targeted therapy olaparib should be re-evaluated for treating metastatic prostate cancer. Read More

After discovering a new mechanism for DNA damage repair last year, Vanderbilt biochemists now provide direct evidence for how it works. Read More

Investigators have discovered how a DNA repair pathway protein shields sites of damage to avoid mutations and maintain genome integrity. Read More

David Cortez and colleagues have found that a protein called RADX helps modulate a protein called RAD51 in order to make sure exactly the correct amount of DNA repair occurs. Read More

Structural details about a protein involved in the repair of damaged DNA provide insight into xeroderma pigmentosum disorders, which are characterized by increased risk for skin cancer. Read More

Vanderbilt researchers uncover the secret of the remarkable potency of the DNA toxin yatakemycin, which could someday be harnessed to fight cancer. Read More

Structural details of a protein that removes DNA lesions shed light on fundamental mechanisms of DNA repair. Read More

Vanderbilt investigators have discovered details about the mechanism of an important DNA repair protein that maintains genome stability. Read More

Telomeres – the caps on the end of chromosomes – are a source of stress for a particular protein involved in copying DNA, a new study reports. Read More

Vanderbilt investigators have generated a “parts list” for the molecular machinery that duplicates DNA each time a cell divides. The research has implications for cancer therapies that target components of this machinery. Read More

Vanderbilt and Stanford investigators have discovered how a protein that's part of the DNA replication "machinery" helps cells tolerate DNA damage. Read More

Insights into the workings of DNA damage response proteins such as SMARCAL1 could suggest new ways to improve genome integrity and prevent cancer. Read More

Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage. Read More

David Cortez, Ph.D., and his Vanderbilt colleagues report new findings that shed light on fundamental processes involved in DNA replication and have implications for cancer therapies that target these processes. Read More

A new tool will allow researchers to identify proteins involved in DNA replication and damage repair, processes that go awry in cancer. Read More