DNA

Nashville Biosciences LLC and Illumina Inc. today announced an agreement with Amgen to whole-genome sequence approximately 35,000 DNA samples. Read More

Assistant Professor of Biochemistry Emily Hodges and graduate student Tyler Hansen used a blended approach to create a new, multi-omic method to identify and characterize gene regulatory elements—non-coding DNA sequences that control gene expression—in the human genome. Read More

Emily Hodges and Terunaga Nakagawa were named as the 2022 Stanley Cohen Innovation Fund recipients. Read More

by Paul Govern Information based biomedical discovery, in particular the push toward precision medicine, depends on open-ended analysis of de-identified data from patients and research participants on the largest possible scale. Sharing data while controlling the risk of data reidentification under privacy attack is vital to the enterprise. Zhiyu Wan Game theory indicates that only... Read More

After discovering a new mechanism for DNA damage repair last year, Vanderbilt biochemists now provide direct evidence for how it works. Read More

Vanderbilt biochemists got unexpected results when they used their new approach to explore the role of DNA methylation in gene regulation. Read More

James Dewar and colleagues have identified a role for the enzyme topoisomerase II in reducing replication errors during the final stage of DNA synthesis. Read More

When it comes to our differences from Neanderthals, most of what we know comes from comparing fossils. But fossils can only tell us about bones and not whole living organisms. That’s changing thanks to a new paper from a team of genomics researchers at Vanderbilt, who… Read More

David Cortez and colleagues have found that a protein called RADX helps modulate a protein called RAD51 in order to make sure exactly the correct amount of DNA repair occurs. Read More

Patients diagnosed with heart failure, stroke, infertility and kidney failure could actually be suffering from rare and undiagnosed genetic diseases. Read More

New mechanistic details about the DNA-unwinding activity of antibacterial protein targets could lead to the design of better antibiotic medicines. Read More

Vanderbilt researchers uncover the secret of the remarkable potency of the DNA toxin yatakemycin, which could someday be harnessed to fight cancer. Read More

Geneticists have developed an effective new method for identifying the genes that produce the chemicals plants use to protect themselves from predators, which are an important natural drug source. Read More

DNA replication is an extraordinarily complex multi-step process that makes copies of the body’s genetic blueprint. It is necessary for growth and essential to life. Now researchers at the California Institute of Technology (Caltech) and Vanderbilt University have found evidence that one of those steps may involve the telephone-like transmission of electrical signals regulated by a chemical “switch.” Read More

“Epigenetic signatures” in DNA may present an opportunity for prevention of or early intervention in childhood obesity. Read More

Imagine a “DNA photocopier” small enough to hold in your hand that could identify the bacteria or virus causing an infection even before the symptoms appear. Read More

Vanderbilt engineers have developed a new method for duplicating DNA that makes devices small enough to hold in your hand that are capable of identifying infectious agents before symptoms appear. Read More

A computer-based method pioneered at Vanderbilt is being used to compare subtypes of rheumatoid arthritis. Read More

There is new evidence that the "mother’s curse" – the possibility that moms may transmit genes to their children that harm their sons but not their daughters – holds true in animals. Read More

A team of Vanderbilt scientists have identified some of the methods that mutant mitochondrial DNA use to circumvent the molecular mechanisms that cells use to regulate mitochondrial activity. Read More