Cholesterol
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Study suggests new mechanism for lipid transporter
A new model suggests that a protein involved in the generation of high-density lipoprotein (HDL) works differently than previously thought. Read MoreSep 15, 2022
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Probing statin-associated diseases with genetics
Vanderbilt researchers used genetics tools and biobanks with linked electronic health records to explore the associations between statins and noncardiovascular diseases. Read MoreJul 12, 2021
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A new contributor to atherosclerosis
Sean Davies and colleagues are exploring lipid aldehydes produced during oxidative stress and their contribution to HDL dysfunction and atherosclerosis. Read MoreJan 27, 2020
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All-in-one pill helps reduce blood pressure, cholesterol
A single pill containing low doses of three medications to treat high blood pressure and one to lower cholesterol reduced the estimated risk of cardiovascular disease by 25%, according to a VUMC study. Read MoreSep 19, 2019
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Scavengers “protect” HDL
Lipid molecules that bind to HDL can modify its function — and blocking that modification can protect HDL and potentially lower the risk of atherosclerosis and heart disease. Read MoreJun 29, 2018
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Oxidative stress on the brain
Vanderbilt investigators have discovered that oxidative damage may play an important role in the development of a rare cholesterol synthesis disease and in the behavioral changes of autism spectrum disorders. Read MoreAug 23, 2017
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VU team explores new cholesterol processing pathway
A zebrafish model of a rare genetic disease has revealed an unexpected regulatory pathway for cholesterol absorption and processing. Read MoreApr 23, 2015
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Kidney disease impacts HDL function
Chronic kidney disease impairs the protective functions of HDL, Vanderbilt researchers report this month. Read MoreFeb 11, 2015
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Team spots key regulator for cholesterol production
A Vanderbilt University-led research team has discovered a “master regulator” for cholesterol production and transport in the liver — a tiny piece of RNA called microRNA-223. Read MoreOct 2, 2014
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Major grant spurs deeper look into ‘good cholesterol’
In some cases, HDL, the "good cholesterol," may not function properly and may actually accelerate atherosclerosis. Read MoreAug 21, 2014
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Antioxidants promising for rare disorder
The antioxidant vitamin E prevented the buildup of toxic products in a model of a rare genetic disorder, suggesting new strategies for therapeutic development. Read MoreFeb 6, 2014
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Nobel laureate describes decades-long pursuit of cholesterol regulation
Nobel laureate Michael Brown, M.D., describes his quest to understand cholesterol during the 2013 Earl W. Sutherland lecture. (Photo by Susan Urmy) Cholesterol is a tricky molecule to keep in balance. It’s a building block for the cell membrane and is required for cell growth and survival. Read MoreMay 2, 2013
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HDL cholesterol impaired in kidney disease
HDL cholesterol is impaired in patients with chronic kidney disease – and may increase their cardiovascular disease risk. Read MoreJan 21, 2013
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Genes, nutrients interact to shape traits
A new study identifies interactions between genes and nutrients that may participate in determining levels of cholesterol and triglycerides. Read MoreDec 12, 2012
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Don’t miss the Love Your Heart Expo Wednesday
(iStock) September is National Cholesterol Education Month and Health Plus is encouraging faculty and staff to get cholesterol checks if recommended, and to take steps to lower cholesterol if it is high. It is also a good time to learn about lifestyle choices that can make a… Read MoreSep 7, 2012
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Gene’s impact on ‘good’ cholesterol could affect heart disease risk
A genetic variant may help keep an individual’s “good” cholesterol in check. Read MoreJul 12, 2012
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Alzheimer’s protein structure suggests new treatment directions
The molecular structure of a protein involved in Alzheimer’s disease – and the surprising discovery that it binds cholesterol – could lead to new therapeutics for the memory-robbing disease. Read MoreMay 31, 2012
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Neuronal clues to cholesterol-defect disorder
Antioxidants may be a beneficial treatment for an inherited genetic disorder. Read MoreApr 20, 2012
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Obesity turns “good” cholesterol bad
Studies offer new insights into how obesity impairs the function of HDL, the “good” cholesterol. Read MoreMar 21, 2012
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Move out, cholesterol
Compounds developed at Vanderbilt could offer a whole new way to treat atherosclerosis. Read MoreDec 8, 2011