Cell And Developmental Biology

Microtubules — cellular “highways” that deliver cargo to the cell membrane for secretion — have a surprising role in pancreatic beta cells. Instead of facilitating glucose-stimulated insulin secretion, they limit it, a team of Vanderbilt investigators reported recently in Developmental Cell. Read More

There’s a little bit of Peru in the Department of Cell and Developmental Biology. Read More

Vanderbilt investigators have defined a gene expression program that controls the timing of synaptic remodeling – a process that is critical to brain development, learning and memory. Read More

A signaling factor called Wnt10b is a novel target for optimizing cardiac repair after a heart attack. Read More

Understanding how signaling molecules are transported within and out of the cell may help to uncover the causes of certain cancers. Read More

Sabine Fuhrmann kicks off the CDB Monday Seminar Series on Aug. 31. Read More

The factor FoxM1 increases the proliferation and function of insulin-producing beta cells, making it an attractive therapeutic target for diabetes. Read More

Vanderbilt’s Ian Macara, Ph.D., has won an Outstanding Investigator Award from the National Cancer Institute (NCI) — nearly $6.6 million over seven years — to support the “unusual potential” of his research, which seeks to understand and predict cancer cell “behavior.” Read More

Ian Macara, Ph.D., professor and chair of the Department of Cell and Developmental Biology, recently returned from Scotland, where he received this year’s Colin Thomson Memorial Medal for his contributions to cancer research. Read More

Our tissues are in a constant state of flux — cells are lost and cells are generated, with local signals and stem cells maintaining the balance, said Roel Nusse, Ph.D., during last week’s Flexner Discovery Lecture. Read More

A zebrafish model of a rare genetic disease has revealed an unexpected regulatory pathway for cholesterol absorption and processing. Read More

New findings suggest that it might be possible to treat diabetes by regenerating insulin-producing beta cells in the pancreas. Read More

TGF-beta signaling in the kidney was thought to be a target for reducing renal fibrosis, but Vanderbilt researchers report that fibrosis still occurs in the absence of TGF-beta signaling. Read More

Roel Nusse, Ph.D., an expert in the regulation of tissue growth and development by Wnt signaling pathways, will deliver the next Flexner Discovery Lecture on Thursday, April 23. Read More

Researchers at Vanderbilt University have discovered a new way to inhibit Hedgehog (Hh) signaling, an important regulatory pathway for vertebrate development – and cancer. Read More

The proteins that control entry and exit from the cell nucleus influence aging, Vanderbilt researchers have discovered. Read More

Vanderbilt University researchers have discovered a cleft in a chromosome-binding protein that may hold the key to stopping most cancers in their tracks. Read More

It’s roughly 5,000 miles from Croatia to Tennessee as the crow flies. Read More

A specific gene expression profile represents a novel, biologically relevant “signature” for identifying colon cancers with high risk of metastatic recurrence, Vanderbilt researchers have found. Read More

New findings suggest a previously unrecognized role for the Sox10 transcription factor in Hirschsprung’s disease, and may lead to improved diagnostic and therapeutic approaches for this disease. Read More