Cancer

Melanoma is the fifth most-common type of cancer in the U.S., and according to the American Cancer Society, about half of patients with malignant melanoma have mutations of the BRAF gene. Identification of potential tumor biomarkers such as SOX10 can help physicians better predict outcomes for their patients.  Read More

New research finds that fully vaccinated patients with cancer who had breakthrough COVID-19 infections remained at high risk for hospitalization and death. Read More

The profile of immune-related gene expression and tumor-infiltrating immune cells in adrenocortical cancer suggests targets for new treatment strategies. Read More

Steven Townsend, associate professor of chemistry, and Fang Yan, research professor of pediatrics and cell and development biology, have discovered how a sugar in human breast milk mitigates damage to the small intestines caused by chemotherapy-induced mucositis. Read More

Following decades of worldwide research standstills on cancer drug improvement, Steven Townsend and his team of researchers synthesize cancer therapeutics that bypass toxicity aimed at heart health. Est. reading time: 2.5 minutes. Read More

Vanderbilt researchers developed new prognostic models for breast cancer outcomes and found that adding postdiagnostic weight change as a factor improves the prediction. Read More

Vanderbilt biochemists have discovered that the protein RADX has different biological effects at sites of DNA synthesis, depending on the cellular conditions — even though it works the same way in both stressed and unstressed cells. Read More

Cancer chemotherapy lowered risk of Alzheimer’s disease and other neurocognitive disorders that disproportionately affect older people. Read More

A new genome-wide CRISPR screening technique conducted by researchers at Vanderbilt University is offering new insights about how tumors in 80 to 90 percent of all cancers grow. Read More

For the second time, cancer researchers at Vanderbilt have discovered a protein that—when genetically manipulated to impede it from interacting with a gene responsible for cancer genesis—effectively melts tumors in days. Read More

William Tansey and colleagues identified proteins that interact with the cancer drug target WDR5 and are important for cancer cell growth. Read More

Vitamin D protection against colon cancer varies according to parathyroid hormone response, particularly among women. Read More

Combining two drugs reduced colorectal cancer cell growth in vitro and in an animal model, suggesting the combination may be a promising treatment for patients. Read More

Vanderbilt scientists have discovered a new target for normalizing tumor blood vessels to improve cancer immunotherapies. Read More

People with inoperable anal cancer treated with carboplatin-paclitaxel had fewer complications and lived longer than those who received another chemotherapy that has been more often administered. Read More

Manuel Ascano team validates an inhibitor of the cGAS-STING signaling pathway, which is important for cellular innate immunity against bacteria, viruses, and our own damaged DNA. Read More

A noninvasive MRI approach assesses breast tumor cell size and could be a useful way to evaluate early response to neoadjuvant therapy. Read More

A newly identified protein interaction that affects cell cycle regulation may be an attractive target for cancer therapy. Read More

Vanderbilt researchers have uncovered another piece in the puzzle of how cells divide — a process that goes awry in cancer cells. Read More

New research from a group of Vanderbilt biomedical engineers reveals that while cancer cells metastasize quickly, they generally choose pathways that use the least amount of energy. Read More