Cancer Drug Discovery

William Tansey and colleagues identified proteins that interact with the cancer drug target WDR5 and are important for cancer cell growth. Read More

A novel immunotherapy combination induced remarkable regression of tumors in a mouse model of head and neck cancer. Read More

A signaling protein overexpressed in upper gastrointestinal cancers is an attractive therapeutic target. Read More

The Robert J. Kleberg Jr. and Helen C. Kleberg Foundation has awarded a $3 million grant to Vanderbilt-Ingram Cancer Center (VICC) investigators in support of VICC’s drug discovery program. The gift awarded over the next three years from the private, San Antonio, Texas-based foundation will enable VICC researchers to pursue the development of new compounds to block the activity of cancer-causing genes and proteins that had previously been considered “undruggable.” Read More

Vanderbilt University has been selected as one of seven Dedicated Centers in the nation for the next phase of the Chemical Biology Consortium (CBC), a national network of scientists on the leading edge of cancer drug discovery. Read More

The primary method used to test compounds for anti-cancer activity in cells is flawed, Vanderbilt University researchers reported May 2 in Nature Methods. Read More

Compounds found in olives and olive oil have anticancer activity, which may contribute to the cancer preventive properties attributed to the Mediterranean diet. Read More

Vanderbilt researchers designed micelle “packets” to selectively deliver anti-cancer drugs to breast cancer cells. Read More

Researchers at Vanderbilt University have discovered a new way to inhibit Hedgehog (Hh) signaling, an important regulatory pathway for vertebrate development – and cancer. Read More

A series of experimental antibiotics may be a good starting point for developing new anticancer drugs. Read More

A new mouse model offers insight into the signaling pathways that control oral cancers – and a platform for testing anticancer therapeutics. Read More

Vanderbilt University investigators have discovered a new molecular mechanism that regulates microtubule dynamics. The unexpected finding, reported in Developmental Cell, has implications for cancer drug discovery. Read More

Vanderbilt investigators have constructed a network map that could guide the development of new targeted cancer therapies. Read More

Vanderbilt researchers have discovered small molecules that turn off cancerous Ras signals in a new way. Read More

David Cortez, Ph.D., and his Vanderbilt colleagues report new findings that shed light on fundamental processes involved in DNA replication and have implications for cancer therapies that target these processes. Read More

Vanderbilt University’s acquisition of a 900 megahertz nuclear magnetic resonance (NMR) spectrometer will accelerate studies on cancer and Alzheimer’s disease. Read More