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antibiotic resistance Archives

Novel infection fighter

Jun. 13, 2018—A drug in use clinically to help make vaccines more effective may be a powerful new tool for fighting antibiotic-resistant infections.

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Bacterial signaling systems

Feb. 3, 2017—Vanderbilt researchers have identified a unique example of communication between bacterial signaling systems, which may have relevance for antibiotic resistance.

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Membrane fats impact drug transporter

Jul. 14, 2016—New studies of a membrane transporter could explain antibiotic resistance – and lead to novel ways to combat it.

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Slight chemical change may improve TB treatments: study

Feb. 11, 2016—One small chemical change to an existing antibacterial drug results in a compound that is more effective against its target enzyme in tuberculosis, Vanderbilt researchers have discovered.

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Dynamics of a drug resistance transporter

Feb. 5, 2016—Vanderbilt investigators are exploring the shape changes in a multidrug transporter to understand the mechanisms of antibacterial resistance.

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Bridging the antibiotic gap

Aug. 7, 2015—Vanderbilt researchers have discovered how certain molecules with antibiotic properties are synthesized, findings that could lead to new drugs that overcome the increased antibiotic resistance in bacteria.

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Vanderbilt-led multi-center study looks at antibiotic choice for treating childhood pneumonia

Jun. 22, 2015—New Vanderbilt-led research shows hospitals are doing a better job of using antibiotics less commonly associated with antibiotic resistance to treat children hospitalized with community-acquired pneumonia (CAP).

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Life’s extremists may be an untapped source of antibacterial drugs

Nov. 21, 2014—A family of single-celled organisms that thrive in environments too extreme for most other species to survive may be an untapped source of new antibacterial drugs.

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Staph ‘gangs’ share nutrients during infection: study

Oct. 16, 2014—Antibiotic-resistant bacteria can share resources to cause chronic infections, Vanderbilt investigators have discovered. The findings shed light on a long-standing question in infectious diseases and may inform new treatment strategies.

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Team finds way to explore ‘super family’ of enzymes

Apr. 24, 2014—Vanderbilt University’s Richard Armstrong, Ph.D., is part of a multi-institutional research team that has found a new way to interrogate a “super family” of enzymes involved in detoxification, cellular metabolism and antibiotic resistance, which have many other as-yet-undiscovered functions.

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Dismantling staph’s drug resistance

Mar. 3, 2014—Targeting the enzyme FosB could make antibiotic-resistant staph bacteria sensitive to the antibiotic fosfomycin.

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Preserving antibiotic arsenal for TB

Oct. 30, 2013—Clinicians should be cautious about prescribing newer fluoroquinolone antibiotics to patients with TB risk factors; doing so may jeopardize the use of these agents against TB.

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