Leigh MacMillan

Death of oligodendrocytes, the cells that make myelin, appears to be an early event in the development of multiple sclerosis. Read More

Vanderbilt researchers used existing genome-wide association study datasets to identify gene interactions that contribute to tooth decay. Read More

A panel of metabolites – small molecules that are part of metabolic processes – that are unique to macular degeneration will shed light on the disease and aid diagnosis. Read More

Molecular characterization of pre-cancerous changes in cells lining the stomach could point to lesions with a greater risk of progression to cancer. Read More

We’re on a potential collision course, said last week’s Flexner Discovery Lecturer, between the delivery of good medical care and the possibilities offered by genome medicine. Read More

Vanderbilt investigators used an in vivo screen in zebrafish to identify a potential new anti-cancer drug. Read More

New mass spectrometry imaging methods will enable studies of the distribution and identification of membrane proteins directly within tissues. Read More

Therapeutic nanoparticles may offer a powerful new way to image and treat cancer at the same time. Read More

Vanderbilt investigators have combined next-generation sequencing technologies and bioinformatics analyses to screen for genome-wide genetic mutations associated with drug resistance in a series of lung cancer cell lines. Read More

Wylie Burke, M.D., Ph.D., an expert in the social, ethical and policy implications of genetic information, will deliver the next Flexner Discovery Lecture on Thursday, Sept. 19. Read More

A coronavirus protein is required for replication of the viral genome and may be a good treatment target for SARS and other diseases caused by coronaviruses. Read More

A new in vitro system will allow investigators to explore how immune system T cells develop specialized functions. Read More

A newly identified factor regulates blood vessel growth in colorectal tumors and could be a promising target for cancer therapies. Read More

Alkaline phosphatase enzymes appear to play roles in promoting pregnancy and in protecting the uterus from bacterial infection. Read More

The nuclear receptor TR3 contributes to ovarian cancer cell death in response to platinum-based chemotherapy – and may be a good target for overcoming cell resistance to certain treatments. Read More

In an effort to understand how neurons develop different “architectures,” Vanderbilt developmental biologists have discovered a genetic switch that controls one type of neuron branching in the nematode worm. Read More

A noninvasive test can be used to identify the presence of Helicobacter pylori and evaluate its virulence, which will be useful in areas with high rates of H. pylori-associated gastric cancer. Read More

Gaining and losing weight during “yo-yo dieting” may contribute to an exaggerated immune response in fat tissue that increases metabolic dysfunction more than steady weight gain alone. Read More

Insight into how the protein neurofibromin participates in the signaling pathway that produces the body’s long bones has implications for fracture healing in some patients. Read More

A motor protein that helps drive cell division may be a promising new target for cancer therapeutics. Read More