Leigh MacMillan

High levels of blood markers for vascular endothelial dysfunction were associated with longer periods of confusion in ICU patients, Vanderbilt researchers have discovered. Read More

Vanderbilt researchers developed a new algorithm to find clinically targetable gene rearrangements in cancers. Read More

Increased activity of the “fight or flight” nervous system contributes to obesity-associated hypertension and may be a good therapeutic target for the disease. Read More

Vanderbilt investigators have demonstrated that a certain protein complex drives tumor progression in aggressive breast cancers. Read More

When Tom Daniel, M.D., joined the Vanderbilt University faculty in December 1986, Stanley Cohen, Ph.D., had just been awarded the Nobel Prize in Physiology or Medicine for his discovery of epidermal growth factor (EGF). Read More

A peptide molecule relaxes airway smooth muscle and may be a potential therapeutic for asthma that has become resistant to standard therapies. Read More

Vanderbilt researchers have discovered that regulation of cell volume plays a role in nerve degeneration and peripheral neuropathies. Read More

Antidepressant use during pregnancy is common. Fetal exposure to the class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs) is associated with the life-threatening condition PPHN (persistent pulmonary hypertension of the newborn), but a causal link has not been established. Read More

During development, neural circuits are remodeled – some synapses are eliminated and others are strengthened – to produce a mature, functional nervous system. Read More

Cells from the bone marrow participate in the development of pulmonary arterial hypertension (PAH), and they can also protect against it, according to new findings from a team of Vanderbilt University Medical Center investigators. Read More

Parenting behaviors may be an important target for improving outcomes in adolescents with diabetes. Read More

Vanderbilt University has been selected as one of seven Dedicated Centers in the nation for the next phase of the Chemical Biology Consortium (CBC), a national network of scientists on the leading edge of cancer drug discovery. Read More

New findings identify isoketal-modified proteins as a previously unrecognized feature of pulmonary fibrosis and as a potential therapeutic target for this disease. Read More

A genetic risk factor for Alzheimer’s disease in later life appears to benefit younger adults as they age. Read More

In a twist on the usual research narrative, Justin Siemann, Ph.D., who celebrated his doctoral degree in Neuroscience at last week’s Graduate School Commencement, conducted research on patients first, and then moved to the laboratory bench. Read More

The primary method used to test compounds for anti-cancer activity in cells is flawed, Vanderbilt University researchers reported May 2 in Nature Methods. Read More

Vanderbilt researchers have discovered that activation of a certain signaling pathway protects brain cancers from targeted therapies, suggesting that using therapeutics that block both pathways may be a promising treatment. Read More

Higher genomic levels of African ancestry are associated with an increased risk for Alzheimer’s disease, a consortium of investigators reported recently in Alzheimer’s & Dementia. Read More

Craig Thompson, M.D., president and CEO of Memorial Sloan Kettering Cancer Center, will deliver the next Flexner Discovery Lecture on May 5. Read More

Eric Betzig, Ph.D., who shared the 2014 Nobel Prize in Chemistry for the development of super-resolved fluorescence microscopy, will deliver the next Flexner Discovery Lecture on April 28. Read More