Science Advances

Researchers at Vanderbilt University Medical Center have identified Rac1, a molecular switch that regulates the actin cytoskeleton of epithelial cells in the collecting ducts, as a driver of post-obstructive kidney repair. Read More

By mapping brain activity in three dimensions, researchers at Vanderbilt University Medical Center have achieved a more detailed picture of how the brain changes with age. Read More

A transcontinental research effort led by scientists from Vanderbilt University Medical Center and the University of Michigan has upended some long-standing assumptions about mutations — how often they occur, what causes them and what they do. Read More

Graduate student measures the coevolution of genes in genomes; method may fundamentally change how we identify genes with similar functions. Read More

by Paul Govern Information based biomedical discovery, in particular the push toward precision medicine, depends on open-ended analysis of de-identified data from patients and research participants on the largest possible scale. Sharing data while controlling the risk of data reidentification under privacy attack is vital to the enterprise. Zhiyu Wan Game theory indicates that only... Read More

Gregor Neuert has discovered that cells respond differently to acute and gradual stress. This finding will transform how cell signaling is understood and inform the drug discovery processes. Read More

Scientists at Vanderbilt University Medical Center and the Translational Genomics Research Institute (TGen) in Phoenix, Arizona, have discovered previously unreported genetic and cellular changes that occur in the lungs of people with pulmonary fibrosis (PF). Read More

Runners could soon keep up with cyclists, thanks to a new exoskeleton invention from a team of mechanical engineers at Vanderbilt which would bring cycling mechanics to the human body. Read More

The identification of a protein important for insulin synthesis may hold clues for understanding the pathogenesis of diabetes. Read More

Vanderbilt investigators have used sophisticated cell biological and structural techniques to “classify” mutations in potassium channels, studies that could lead to personalized treatment of heart rhythm disorders. Read More

Genetic mutations in PMP22 (peripheral myelin protein 22) cause a variety of peripheral neuropathies, underscoring the importance of the protein to a healthy peripheral nervous system. But the precise function of PMP22, a major component of the myelin sheath that surrounds and insulates peripheral nerve cell axons, has been unclear. Read More

Vanderbilt researchers found a place where early Americans paused on their migrations south and "settled in for a good long while," suggesting a slower pace of settlement than originally believed. Read More

A new protein structure may guide the development of Alzheimer's therapeutics. Read More

A research team led by structural biologists from Vanderbilt University has come up with the first detailed molecular explanation for a factor that may contribute to the so-called cystic fibrosis (CF) “gender gap.” Read More