School Of Medicine Basic Sciences

Vanderbilt’s undergraduate, graduate and professional schools are taking on the challenges of an ever-evolving world with dozens of new courses and programs for the 2026–27 school year. Here are some of the new academic ways the university is preparing students to combine knowledge and vision to create future impact. Read More

Vanderbilt researchers are hunting down ways to combat Alzheimer’s by developing compounds that affect the proteins that are linked to it. TAOK-1 is such a protein, but it has not been thoroughly studied because there wasn’t a “tool compound” to study it with. Former postdoctoral fellow Daniel Schultz and Ph.D. student Lauren Parr have developed two such compounds—one that inhibits TAOK-1, and another that activates the entire TAOK protein family—through work conducted in the WCNDD, led by Executive Director Craig Lindsley. Read More

Think of cells as factories that hold sets of machines doing different things. How those machines are organized and used determines the efficiency of the factory. Vanderbilt researchers are looking into how cells reorganize those machines over time—and what that means for aging. They’re focused on a cell structure (machine) called the ER, which is known to be vital to cell processes but has not yet been thoroughly studied. “Changes in the ER occur relatively early in the aging process,” says Assistant Professor Kris Burkewitz. “One of the most exciting implications of this is that it may be one of the triggers for what comes later: dysfunction and disease.” And identifying the trigger could lead to being able to stop the firing. Read More

For patients with advanced melanoma without BRAF mutation who no longer respond to immune checkpoint inhibitors, treatment options remain frustratingly limited. A new study from Vanderbilt researchers led by Professor Emerita of Pharmacology Ann Richmond outlines a promising therapeutic strategy that may re-sensitize these resistant tumors to immunotherapy. Read More

Vanderbilt University has announced its fall 2025 recipients of the Seeding Success, Scaling Success and Rapid-Advancement MicroGrant Program awards, providing internal funding to help faculty launch new research directions, strengthen proposals and compete for major external grants. Read More

Research into combating cocaine addiction has been limited by the difficulty in structuring accurate animal models; standard practice relies on implanting IV catheters that the animals can use to self-dose. Now Assistant Professor Cody Siciliano's lab has devised a method that more closely mimics cocaine use in humans—effectively, a way for the animals to snort cocaine. This makes the animal model more analogous to human experience, and it reduces surgical and intravenous procedures for the animals. "This model provides a powerful framework for linking motivated drug use with real-time neural activity, offering new opportunities to study the circuitry underlying reinforcement and decision-making," Siciliano said. Read More

New drug discovery institute brings together AI, genomics, systems biology and translational research to accelerate cures for major diseases. Read More

A new potential treatment for schizophrenia discovered through the Warren Center for Neuroscience Drug Discovery has entered phase 1 clinical trials, marking the fifth WCNDD therapeutic to advance into human testing. Read More

Schizophrenia has been proven to be heritable, but typical analyses so far haven’t been able to pinpoint what, genetically, is going wrong in the brain. A new paper by Professor Bingshan Li and research instructor Rui Chen outlines how to improve on existing genetic screening for schizophrenia risk by expanding the areas of the chromosome scanned for genetic signals. Their results point to a “tangible biological pathway—and potential treatment target—linking genetic risk to the pathogenesis of schizophrenia,” Chen said. Read More

Shan Meltzer has been awarded a prestigious Edward Mallinckrodt, Jr. Foundation Award to advance her pioneering research that seeks to determine how the body’s sensory circuits form and function. Her work seeks to answer a fundamental question in neuroscience: how do the brain and spinal cord organize their intricate networks to perform such a wide range of functions? Read More

Vanderbilt supports new faculty every step of the way—by connecting them with senior faculty who serve as mentors, observe their classes and provide valuable feedback, and proofread their grant proposals to make them stronger. These professors who joined Vanderbilt in the past few years shed light on how the university has helped them succeed.  Read More

The role of artificial intelligence in drug discovery has been limited by machine learning methods that fail when they encounter chemical structures they weren’t “trained” on. Assistant Professor Benjamin Brown has written a paper suggesting a more targeted approach: using a task-specific model architecture that’s intentionally restricted to learn from a representation of the interaction space between a protein and a drug molecule and be better able to generalize and figure out which compound might best interact with that protein. That’s important, because identifying those compounds early cuts the costs and time involved in developing drugs. Read More

Advanced melanoma can be notoriously resistant to standard immunotherapy, but a new drug combination might hold some hope for patients with this most common form of skin cancer. Professor Emerita of Pharmacology Ann Richmond and her team, in preclinical work, created a “tumor microenvironment more receptive to immune challenge.” The treatment slowed tumor growth, showed stronger immune responses and increased helpful T cells. It could be on a faster-than-typical track to human studies because all the drugs are already involved in other clinical trials. Read More

Kathleen DelGiorno, assistant professor of cell and developmental biology, has received a Research Scholar Award from the American Cancer Society. The award will fund research into potential therapies against pancreatic cancer, the third-leading cause of cancer-related deaths in the United States, which is forecast to become the second-leading cause by 2030. Read More

Vanderbilt researchers, including those from the Vanderbilt Brain Institute, have made significant strides in understanding how the enteric nervous system—sometimes called the “brain” of the gut—forms and functions. Read More

When we think of the age-old adage about getting old, “What new ache or pain will each new day bring?” we often imagine ailments such as joint or bone pain, a hyperactive bladder, or even memory loss, but Kevin Schey, Stevenson Professor of Biochemistry at the School of Medicine Basic Sciences, thinks a lot about the loss of eyesight. Read More

James Hayes, Rekha Nagarajan and James Costanzo are the winners of the 2025 Cell Imaging Shared Resource Life Is Beautiful Image Contest. They worked with Jenny Schafer, CISR managing director and research associate professor of cell and developmental biology, Oleg Kovtun, research assistant professor of chemistry, and CISR senior research specialists Kari Seedle and Tegy Vadakkan to create these images as part of their individual research projects. Read More

Three Vanderbilt faculty members are diving into a "chicken-and-egg" problem of type 2 diabetes: Does the disease change beta-cell subtypes? Or do changes in the cells cause diabetes? Guoqiang Gu, Emily Hodges and Ken Lau have come up with a new method of studying the subtypes that can track them through different stages instead of just once when they're fully developed. "Thanks to this and other research, it may be possible to one day create a diet supplement for pregnancy that could reduce the risk of diabetes for babies," Gu said. Read More

Five Vanderbilt researchers have received Seeding Success grants for early-stage projects that have strong potential for external funding. The program, managed by Research Development and Support, reflects the university’s commitment to advancing high-impact research across disciplines. Read More

In a scientific first, researchers from Vanderbilt University and the University of California, San Diego, have generated a high-resolution metabolic “map” of how cells orchestrate glucose processing, revealing a hidden world where organelles and molecular complexes collaborate when responding to a rush of nutrients. This new study, published in Nature Communications, has redefined how glucose metabolism is visualized at the single-cell level. Read More