NIH

New research into the enzyme topoisomerase II sheds light on how it helps DNA replicate properly. Read More

David Cortez and colleagues have discovered a new DNA repair mechanism. Read More

People with low levels of endocannabinoids, which stimulate the same brain receptors turned on by the active ingredient in marijuana, experience greater pain relief from opioids than those with high levels. Read More

A new biomaterial-based bone graft extender created by Vanderbilt and U.S. Army researchers has the potential to improve treatment of critical orthopedic conditions. Read More

Identifying and quantifying skin lesions often requires hours of tedious visual inspection by experts, making it difficult to study a lot of them at once. Eric Tkaczyk and Daniel Fabbri have found that training multiple non-experts to do basic evaluations can achieve comparable results. Read More

An international team involving Vanderbilt researchers has discovered that a new “checkpoint” protein on immune system cells is active in tumors, and that blocking it — in combination with other treatments — is a successful therapeutic approach in mouse models of cancer. Read More

Matthew Tyska and colleagues have found that an adhesion protein in the gut is necessary for proper intestinal functioning. Read More

Danny Winder and colleagues have demonstrated how norepinephrine and a stress factor call CRF interact, which may lead to new treatments for stress-related disorders. Read More

Timothy Cover, john Loh and colleagues have identified how a certain type of mutation influences the risk of premalignant and malignant changes in the stomach. Read More

Inhibiting COX-2 — an enzyme associated with inflammation — could provide a novel therapeutic approach for stress-related psychiatric disorders. Read More

The NIH has now posted information for the 2019 S10 Shared and High-end Instrumentation Grants programs. Read More

Craig Brooks and colleagues have identified a mechanism of kidney fibrosis progression, suggesting a potential new angle for treating chronic kidney disease. Read More

Heather Pua and colleagues have identified the source of cellular signals that may play a role in triggering an asthma attack. Read More

Older patients with a diagnosis of chronic sinusitis have a unique inflammatory signature that may render them less responsive to steroid treatment, according to new research led by Justin Turner. Read More

Walter Chazin and colleagues have identified how a chemical "switch" in DNA primase, an enzyme essential to the replication of our genomes, works in order to hand off genetic information to the next enzyme. Read More

Carlos Lopez, Tina Iverson and Vsevolod Gurevich propose that a conveyer belt best describes the mechanism by which cellular signals are handed off from enzyme to enzyme in the brain. Read More

Ken Lau and Guoqiang Gu have identified a critical biomarker in determining how a pancreatic progenitor cell will develop. Read More

Brian Engelhardt is studying why as many as 50 percent of stem cell transplant recipients develop diabetes. Read More

David Aronoff and colleagues report an increased risk of the serious gastrointestinal infection C. diff following the use of NSAID pain relievers. Read More

A team led by biomolecular engineer John Wilson and cancer biologist Rebecca Cook have found a way to trigger an immune response that targets breast cancer cells. Read More