NIH

Jeffrey Rathmell and colleagues show that a drug that inhibits glutamine metabolism — currently in clinical trials as an anticancer agent — might also be useful as a treatment for inflammatory and autoimmune diseases. Read More

This work was the foundation for an NSF grant to interrogate how the Rif1 protein controls DNA replication. Read More

James Patton and colleagues have demonstrated how colon cancer cells transmit genetic data to other cells. Read More

A new link between a support protein within the brain's white matter and known Alzheimer's biomarkers discovered by Angela Jefferson and colleagues bring researchers a step toward earlier and more precise detection of neuropathology underlying cognitive impairment that may lead to new targeted therapies Read More

Raymond Harris, Ming-Zhi Zhang and colleagues suggest pathways activated by the epidermal growth factor receptor may be promising targets for treating diabetic kidney disease. Read More

New findings by Dawn Newcomb and colleagues suggest an explanation for why women are more prone to asthma than men. Read More

Research led by Sanjay Mishra, and colleagues suggests modular sHSP architecture contributes to the ability of heat-protective proteins to serve as chaperones for a range of unfolded proteins. Read More

Loss of a protein that regulates mitochondrial function can greatly increase the risk of a heart attack, report Eric Gamazon, Sandra Zinkel and graduate students Christie Salisbury-Ruf and Clinton Bertram in new research. Read More

The hidden lives of medical biomarkers are the focus of a recent study in Nature Communications by Jonathan Mosley. Read More

Reyna Gordon has received a NIH Director’s New Innovator Award of $2.3 million for her project, “Biomarkers of Rhythmic Communication: Integrating Foundational and Translational Approaches.” Read More

A new study by Harvey Murff finds that diabetics who take metformin have lower rates of liver cancer than those who take other diabetes drugs. Read More

Stephen Deppen and colleagues have developed an updated map showing new areas of increased risk for a common lung infection. Read More

Research led by Matthew Tyska gives new insight into the formation of the lining of the gut that helps us absorb nutrients and guard against illness. Read More

Researchers led by melanoma researcher Douglas Johnson have answered questions about the incidence and timing of rare but sometimes fatal reactions to the most widely prescribed class of immunotherapies. Read More

An immune cell called CD8+ is supposed to attack disease, but it can also contribute to inflammation, which can lead to insulin resistance and type 2 diabetes. Read More

New research by an international team that includes Vanderbilt researchers shows how a common diabetes drug blocks glucose production by the liver, suggesting new avenues for treatment. Read More

There’s promise in specific immune system peptides—amino acid compounds that signal cells how to function. In this case, they may be affecting brain activity and, by extension, drug cravings. Read More

The discovery of these antibodies could significantly improve the diagnosis and treatment of the leading cause of stomach illness in the world. Read More

The discovery that high levels of bile acids appear to blunt cravings for cocaine could lead to new treatments for addiction. Read More

James Galligan and Lawrence Marnett have discovered a new histone modification that can affect gene expression. Read More