NHLBI

Vanderbilt investigators identify a new therapeutic target for the inflammatory lung disease sarcoidosis. Read More

Stem cells derived from patients with pulmonary arterial hypertension provide a unique resource for studying the molecular defects that cause the disease and testing potential therapies. Read More

Up to 60 percent of patients who receive a stem cell transplant using cells from another donor will develop post-transplant diabetes mellitus, which can increase the rate of complications and death after the procedure. Read More

In some cases, HDL, the "good cholesterol," may not function properly and may actually accelerate atherosclerosis. Read More

Endothelial cells residing in the coronary arteries can function as cardiac stem cells to produce new heart muscle tissue, Vanderbilt University investigators have discovered. Read More

Vanderbilt researchers have discovered that the protein CRADD counteracts inflammatory injury to endothelial cells, which could assist the development of new therapies for inflammatory vascular disorders. Read More

Understanding how to control the generation of regulatory T cells could have important implications for treating autoimmunity and cancer. Read More

Virus-like particles containing a protein from human metapneumovirus are a promising vaccine candidate for this respiratory virus. Read More

A particular anti-arrhythmia drug provides a targeted treatment for certain forms of atrial fibrillation. Read More

A new compound that activates potassium channels could be used to treat disorders of glucose homeostasis. Read More

Smooth muscle cells that line the aorta differ in development but not in the adult, a finding that has implications for understanding aortic development and disease. Read More

Electronic medical records linked to DNA biobanks are a valid resource for defining and understanding the genetic factors that contribute to drug response. Read More

Patients who suffer a longer duration of delirium in the intensive care unit are more likely to experience long-term disability after discharge. Read More

The pulmonary arterial hypertension knowledgebase (PAHKB), developed by Vanderbilt researchers, provides a useful tool for identifying PAH-related genes and signaling pathways relevant to pathogenesis. Read More

A new mouse model reveals gene clusters important in a treatment-resistant form of leukemia. Read More

Variation in the gene for the beta-1 adrenergic receptor increases the risk that a patient will have an abnormal heart rhythm after cardiac surgery. Read More

Vanderbilt researchers are studying how mutations in the receptor for light, rhodopsin, cause light blindness. Read More

Importin alpha 5, a member of a family of proteins that “shuttle” other proteins into the nucleus, is a potential new target for drugs to treat inflammatory diseases. Read More

Vanderbilt investigators used an in vivo screen in zebrafish to identify a potential new anti-cancer drug. Read More

A new in vitro system will allow investigators to explore how immune system T cells develop specialized functions. Read More