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NHLBI Archives

Scavengers “protect” HDL

Jun. 29, 2018—Lipid molecules that bind to HDL can modify its function — and blocking that modification can protect HDL and potentially lower the risk of atherosclerosis and heart disease.

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A “public” target for HIV

Jun. 8, 2018—Common sequences of antibodies against HIV may be key to developing a successful vaccine strategy for the virus.

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Enzyme protects against obesity-related heart disease

Jun. 7, 2018—Vanderbilt scientists have discovered that a certain enzyme plays a crucial role in preventing obesity-related cardiac dysfunction.

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Putting the brakes on sepsis

May. 9, 2018—An enzyme called PTEN reduces inflammatory signaling and mortality in sepsis, suggesting it may be a good therapeutic target for this life-threatening complication of infection.

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Understanding HDL structure

May. 3, 2018—Structural features of newly formed HDL particles will help guide understanding of “good cholesterol” and its function.

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Gene expression in mitral valve disease

Apr. 25, 2018—A protease gene family may be new targets for treating mitral valve disease, which causes blood to flow backwards in the heart.

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Disease-fighting antibody production

Apr. 20, 2018—New research links nutrient-responsive cellular signaling to the antibody-mediated immune response.

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New view of the heartbeat

Apr. 6, 2018—Structural views of the proteins that regulate the heartbeat may help improve existing treatments for cardiac arrhythmias.

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Lung diseases share molecular signature

Apr. 5, 2018—Lung diseases of infancy and aging share a molecular signature, pointing to a potential target for treatment and prevention.

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Alzheimer’s proteins in ICU survivors

Mar. 27, 2018—The cognitive impairment that affects patients who survive a stay in the ICU does not appear to have a similar mechanism to Alzheimer’s disease, Vanderbilt researchers have discovered.

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Boys, girls reach activity levels in different ways

Mar. 15, 2018—Most preschool-age children manage to get enough recommended daily physical activity, but how they move varies with noticeable differences between boys and girls, a new Vanderbilt study found.

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Long QT syndrome – revealed

Mar. 12, 2018—Vanderbilt investigators have used sophisticated cell biological and structural techniques to “classify” mutations in potassium channels, studies that could lead to personalized treatment of heart rhythm disorders.

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