NHLBI
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Race, hormones and diabetes risk
Variation in the levels of hormones called natriuretic peptides may contribute to racial differences in susceptibility to diabetes, suggesting that this hormone system may be a target for reducing risk of the disease. Read MoreApr 8, 2020
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Clues to lung injury in preterm babies
Jennifer Sucre and colleagues have discovered a factor that contributes to the pathological changes of bronchopulmonary dysplasia, the most common complication of preterm birth. Read MoreMar 5, 2020
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A new contributor to atherosclerosis
Sean Davies and colleagues are exploring lipid aldehydes produced during oxidative stress and their contribution to HDL dysfunction and atherosclerosis. Read MoreJan 27, 2020
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Protein dynamics in the beating heart
To study the dynamics of structural proteins in the heart, Vanderbilt investigators generated a cellular tool they expect will be useful for screening drugs that affect heart muscle contraction. Read MoreDec 16, 2019
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Less inflammation = better healing
Immune cells that produce an anti-inflammatory factor are enriched in fat tissue around the heart and may be good targets to improve heart attack outcomes. Read MoreOct 17, 2019
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AI maps routes to heart disease
Machine learning on unlabeled electronic health record data has shed light on the emergence of cardiovascular disease. Read MoreOct 7, 2019
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Pua lands NIH Director’s New Innovator Award
Heather Pua, MD, PhD, one of 60 investigators to receive the 2019 NIH Director’s New Innovator Award, will explore a novel type of cell signaling by RNAs in allergic airway inflammation. Read MoreOct 1, 2019
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Tailoring treatment for heart defect
By defining the clinical and genetic factors that predict treatment response, Vanderbilt investigators aim to personalize therapy for a common heart complication in preterm infants. Read MoreSep 23, 2019
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How salt increases blood pressure
Vanderbilt researchers have discovered that a protein called SGK1 in immune cells is activated by sodium, leading to the development of salt-sensitive hypertension. Read MoreSep 5, 2019
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New look at atherosclerosis
A new imaging method makes it possible to directly measure cell division and changes in metabolism in atherosclerotic plaques. Read MoreJul 11, 2019
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Study seeks to expand treatment options for rare airway disease
Idiopathic subglottic stenosis is an unexplained narrowing of the windpipe just below the vocal cords. The disease is progressive, slowly affecting the patient’s ability to breathe, and can be fatal due to airway obstruction if left untreated. Read MoreJun 14, 2019
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Cell-cell signals in developing heart
Scott Baldwin and colleagues have discovered early signaling events during heart development, findings that could guide cell replacement therapies for heart disease. Read MoreJun 10, 2019
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Cardiac dysfunction in Duchenne’s
Jonathan Soslow and colleagues have found more clues to why people with Duchenne muscular dystrophy are at risk for a certain kind of heart problem. Read MoreApr 4, 2019
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Parsing diabetic skin infections
People with diabetes may be prone to more skin infections due to an overabundance of a compound that controls inflammation in the body. Read MoreNov 30, 2018
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Team’s findings show glutamine metabolism affects T cell signaling
Jeffrey Rathmell and colleagues show that a drug that inhibits glutamine metabolism — currently in clinical trials as an anticancer agent — might also be useful as a treatment for inflammatory and autoimmune diseases. Read MoreNov 1, 2018
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Mass spectrometry team earns grant to map body at the cellular level
Biochemistry professor Richard Caprioli, director of the Mass Spectrometry Research Center, and Jeff Spraggins, research assistant professor of biochemistry, and their team will build a platform to molecularly characterize cells. Read MoreSep 28, 2018
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Scavengers “protect” HDL
Lipid molecules that bind to HDL can modify its function — and blocking that modification can protect HDL and potentially lower the risk of atherosclerosis and heart disease. Read MoreJun 29, 2018
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A “public” target for HIV
Common sequences of antibodies against HIV may be key to developing a successful vaccine strategy for the virus. Read MoreJun 8, 2018
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Enzyme protects against obesity-related heart disease
Vanderbilt scientists have discovered that a certain enzyme plays a crucial role in preventing obesity-related cardiac dysfunction. Read MoreJun 7, 2018
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Putting the brakes on sepsis
An enzyme called PTEN reduces inflammatory signaling and mortality in sepsis, suggesting it may be a good therapeutic target for this life-threatening complication of infection. Read MoreMay 9, 2018