Mitochondria

A collaborative project between the labs of Maulik Patel and Kris Burkewitz has identified a new molecular pathway that plays a key role in the ability of cells to sense and respond to stressed mitochondria. Read More

Oxidative stress and toxic products called isolevuglandins in mitochondria play a role in endothelial dysfunction and hypertension — and getting rid of them with a special “scavenger” molecule has therapeutic potential. Read More

Tina Iverson and colleagues provide a structural view into the assembly of a protein machine essential for cellular energy production. Read More

A disease-associated mutation in a transporter protein causes cells to increase energy production, as if they are starving, Vanderbilt researchers have discovered. Read More

New findings suggest that oxidative stress damages mitochondrial DNA, and they link this damage to a disease state. Read More

There is new evidence that the "mother’s curse" – the possibility that moms may transmit genes to their children that harm their sons but not their daughters – holds true in animals. Read More

A team of Vanderbilt scientists have identified some of the methods that mutant mitochondrial DNA use to circumvent the molecular mechanisms that cells use to regulate mitochondrial activity. Read More

Mitochondria not only are the cell’s main power producers, they are also the chief cooks and bottle washers. Read More

A person’s mitochondrial gene “signature” could predict risk for diabetic retinopathy and guide early intervention strategies. Read More

A study of mitochondrial DNA mutations suggests they result from a process that selects for particular mutations in certain tissues. Read More

A zebrafish model of a severe mitochondrial disease will be useful for developing new therapeutic approaches. Read More

Study finds no evidence of increased mitochondrial mutations in the children of women treated with radiation for cancer. Read More

Vanderbilt researchers provide new information about how the genome inside our cellular “power plants” – the mitochondria – has evolved. Read More