Microtubules
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Vanderbilt team works across disciplines to replicate cellular filament behavior for the first time, shedding new light on a fundamental cellular process
Cell biologists, physicists and computer scientists use computational modeling to pinpoint the components that shape cell behavior. Read MoreSep 8, 2020
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The plus and minus of microtubules
Understanding the dynamic regulation of cytoskeletal microtubules may suggest new ways to treat disorders ranging from Alzheimer's disease to cancer. Read MoreSep 5, 2019
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New role for microtubules in diabetes
Microtubules, part of the cell's cytoskeleton, regulate the secretion of insulin, suggesting that they may be a new target for treating diabetes. Read MoreJul 29, 2019
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Cell skeleton and the brush border
Vanderbilt researchers have discovered a role for microtubules — part of the cellular “skeleton” — in organizing the unique sidedness of the epithelial cells that line organs like the intestines. Read MoreJan 31, 2018
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Research sheds light on how microtubules are assembled
Microtubules are the “railroad tracks” essential for moving intracellular “freight” around in the cell. They’re also part of the spindle that pulls the two centrosomes apart during cell division. Read MoreJan 4, 2018
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Microtubules act as cellular ‘rheostat’ to control insulin secretion
Microtubules — cellular “highways” that deliver cargo to the cell membrane for secretion — have a surprising role in pancreatic beta cells. Instead of facilitating glucose-stimulated insulin secretion, they limit it, a team of Vanderbilt investigators reported recently in Developmental Cell. Read MoreDec 3, 2015
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Zanic’s journey to the lab followed winding path
It’s roughly 5,000 miles from Croatia to Tennessee as the crow flies. Read MoreMar 5, 2015
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VU study reveals factor’s new role in cell division, migration
Vanderbilt University investigators have discovered a new molecular mechanism that regulates microtubule dynamics. The unexpected finding, reported in Developmental Cell, has implications for cancer drug discovery. Read MoreOct 30, 2014