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Martin Egli

Grant enhances study of new chemotherapy targets

Oct. 19, 2018—Vanderbilt chemists have been awarded $7.2 million over the next five years from the National Cancer Institute to lead an initiative to better understand how a combination chemotherapy for breast cancer targets DNA.

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Altered metabolism and disease

Jul. 25, 2017—Vanderbilt researchers report a structure of a human metabolic enzyme bound to its substrate 17alpha-hydroxyprogesterone.

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Faulty building blocks in DNA

Jan. 22, 2016—An enzyme that builds DNA is able to insert the wrong building blocks, which could generate mutations.

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Bypassing DNA damage

May. 9, 2014—Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage.

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Carcinogenic chemicals cramp DNA

Nov. 21, 2012—Researchers have determined how a DNA lesion caused by exposure to chemicals may spark cancer formation.

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DNA: From modification to mutation

Jun. 8, 2012—Understanding how an environmental hazard damages DNA may shed light on processes of tumor formation.

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Fungus toxin gets in the way in DNA

Oct. 7, 2011—Structural studies are providing insight to how aflatoxin – a toxin produced by fungi – contributes to cancer development.

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Fluorine aids gene silencing

Feb. 15, 2011—Modifying a form of RNAs may improve their efficacy for research and medical uses.

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