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Grant enhances study of new chemotherapy targets
Vanderbilt chemists have been awarded $7.2 million over the next five years from the National Cancer Institute to lead an initiative to better understand how a combination chemotherapy for breast cancer targets DNA.
Oct 19, 2018
Altered metabolism and disease
Vanderbilt researchers report a structure of a human metabolic enzyme bound to its substrate 17alpha-hydroxyprogesterone.
Jul 25, 2017
Faulty building blocks in DNA
An enzyme that builds DNA is able to insert the wrong building blocks, which could generate mutations.
Jan 22, 2016
Bypassing DNA damage
Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage.
May 9, 2014
Carcinogenic chemicals cramp DNA
Researchers have determined how a DNA lesion caused by exposure to chemicals may spark cancer formation.
Nov 21, 2012
DNA: From modification to mutation
Understanding how an environmental hazard damages DNA may shed light on processes of tumor formation.
Jun 8, 2012
Fungus toxin gets in the way in DNA
Structural studies are providing insight to how aflatoxin – a toxin produced by fungi – contributes to cancer development.
Oct 7, 2011
Fluorine aids gene silencing
Modifying a form of RNAs may improve their efficacy for research and medical uses.
Feb 15, 2011