Journal Of Clinical Investigation

Vanderbilt researchers have uncovered a potential new way to help curb the rapidly rising worldwide prevalence of metabolic disorders, including obesity and diabetes. Read More

Vanderbilt investigators have discovered a molecular mechanism that promotes chronic kidney disease following kidney injury. Read More

Vanderbilt research that promotes the anti-inflammatory pathway in macrophages could also reduce some of the bad side effects of obesity. Read More

Researchers at Vanderbilt University Medical Center have identified potential new targets for the prevention of atherosclerosis through the enhancement of autophagy, a natural process for recycling damaged cellular material. Read More

An FDA-approved medication enhances the function of T regulatory cells (Treg), a class of immune cells that restrains the immune response, Vanderbilt investigators have discovered. Read More

Post-transplantation diabetes mellitus (PTDM), a common complication of immunosuppressive drugs that are given to prevent transplant rejection, may be reversible and at least partially preventable, researchers at VUMC report. Read More

A first-of-its-kind mouse model may help reveal mechanistic underpinnings for the altered behaviors of autism spectrum disorder. Read More

A novel population of lung stem cells plays an important role in regulating the pulmonary microvasculature — the network of tiny blood vessels where oxygen and carbon dioxide exchange takes place. Read More

Salted peanuts make you thirsty so you drink more: that’s bartender wisdom. While that may be true in the short-term, within 24 hours increasing salt consumption actually makes you less thirsty because your body starts to conserve and produce water. Read More

Researchers at Vanderbilt University School of Medicine have uncovered a link between epidermal growth factor receptor (EGFR) signaling and the inflammatory response to bacterial infection in the gastrointestinal tract. Read More

Researchers at Columbia and Vanderbilt universities have made an important discovery in mice that has implications for understanding the gastrointestinal (GI) problems experienced by some children with autism. Read More

A microRNA — a small piece of RNA involved in regulating gene expression — functions as an oncogene to drive the development of lung cancer, Vanderbilt University investigators have discovered. Read More

A team of Vanderbilt University Medical Center scientists are closer to understanding why COX-2 inhibitors — drugs that relieve arthritis pain and inflammation without the gastrointestinal side effects of other painkillers — cause heart problems in some patients. Now Read More

New findings show that fibrin, a protein that was thought to play a key role in fracture healing, is not required, shifting understanding of how fractures heal. Read More

An antioxidant protein may protect against colon cancer that develops in patients with inflammatory bowel disease, suggesting new strategies for reducing colon cancer risk in these patients. Read More

Vanderbilt University researchers have come closer to solving a mystery that has puzzled scientists for more than a century: after the loss of one kidney, what causes the growth of the remaining kidney to take up the slack? Read More

With the help of a computer program called “Rosetta,” researchers at Vanderbilt University have “redesigned” an antibody that has increased potency and can neutralize more strains of the AIDS-causing human immunodeficiency virus (HIV) than can any known natural antibody. Read More

Changes in the kidney can limit the blood pressure-lowering effects of thiazide diuretics, a new study reports. Read More

A particular genetic mutation combined with an urban environment increases the risk of severe disease in children infected with respiratory syncytial virus (RSV), an international team of investigators has found. Read More

The evidence is increasing: the immune system and inflammation are key contributors to high blood pressure. Read More