Journal Of Biological Chemistry

Vanderbilt researchers have discovered steps in the regulation of a key enzyme that builds the basement membrane, a structure that undergirds nearly all animal tissues. Read More

New structural details of the binding of the bacterium Streptococcus sanguinis to platelets may offer new therapeutics for life-threatening cardiovascular infections. Read More

Vanderbilt investigators have discovered details about the mechanism of an important DNA repair protein that maintains genome stability. Read More

Vanderbilt researchers have defined a mechanism that limits liver cell proliferation after injury in order to preserve critical metabolic functions. Read More

An enzyme that builds DNA is able to insert the wrong building blocks, which could generate mutations. Read More

Structural and molecular details of an anti-fungal target's interaction with inhibitors suggest ways to design better treatments for fungal infections. Read More

Understanding the action of a certain enzyme will shed light on basement membrane function, and on disorders ranging from diabetic kidney disease to cancer. Read More

Dietary vitamin C may maintain healthy blood vessels in patients with inflammatory diseases. Read More

Vanderbilt investigators have discovered how mammals, including humans, produce the painkiller morphine. Read More

Vanderbilt University’s F. Peter (Fred) Guengerich, Ph.D., has been named interim editor-in-chief of the Journal of Biological Chemistry (JBC). Read More

Vanderbilt researchers have discovered a novel mechanism for the development of dendritic spines – sites of nerve cell communication. Read More

Compounds developed at Vanderbilt University may offer a new way to block influenza infection. Read More

Vanderbilt researchers have discovered that the protein CRADD counteracts inflammatory injury to endothelial cells, which could assist the development of new therapies for inflammatory vascular disorders. Read More

The protein CaMKII acts as a calcium sensor in a positive feedback pathway that enhances glucose-stimulated insulin secretion. Read More

Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage. Read More

Vanderbilt University researchers have discovered a “backdoor” approach to blocking an enzyme that fuels the growth of glioblastoma, the most common and most fatal form of brain cancer. Read More

Removal of the neurotransmitter norepinephrine from the space outside cells plays an important role in the regulation of bone remodeling. Read More

Researchers have determined how a DNA lesion caused by exposure to chemicals may spark cancer formation. Read More