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Journal of Biological Chemistry Archives

A spicy finding

Jan. 16, 2018—Vanderbilt researchers have discovered that curcumin — the active ingredient in the spice turmeric — needs to be metabolically activated to exert anti-inflammatory effects.

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Forming memories through CaMKII

Dec. 19, 2017—Vanderbilt researchers have identified an interaction between two proteins that play a role in learning and memory.

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DNA damage repair: molecular insights

Dec. 5, 2017—Structural details about a protein involved in the repair of damaged DNA provide insight into xeroderma pigmentosum disorders, which are characterized by increased risk for skin cancer.

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Fighting fungal infections

Apr. 3, 2017—A detailed structural and functional analysis of the yeast protein that is the main target of antifungal drugs will help direct efforts to develop better treatments.

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Protecting the blood-brain barrier

Dec. 9, 2016—Vanderbilt investigators have discovered how a promising cancer immunotherapy causes brain swelling, findings that could lead to ways to protect brain function while fighting cancers.

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Reducing antidepressants’ side effects

Nov. 23, 2016—Vanderbilt investigators have discovered how antidepressant medicines that block serotonin uptake can increase bleeding risk.

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Building the basement membrane

Nov. 21, 2016—Vanderbilt researchers have discovered steps in the regulation of a key enzyme that builds the basement membrane, a structure that undergirds nearly all animal tissues.

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How strep grabs on to platelets

Apr. 20, 2016—New structural details of the binding of the bacterium Streptococcus sanguinis to platelets may offer new therapeutics for life-threatening cardiovascular infections.

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Mechanism of a DNA repair protein

Apr. 15, 2016—Vanderbilt investigators have discovered details about the mechanism of an important DNA repair protein that maintains genome stability.

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Liver balancing act

Feb. 24, 2016—Vanderbilt researchers have defined a mechanism that limits liver cell proliferation after injury in order to preserve critical metabolic functions.

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Faulty building blocks in DNA

Jan. 22, 2016—An enzyme that builds DNA is able to insert the wrong building blocks, which could generate mutations.

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Rational design of novel antifungals

Oct. 7, 2015—Structural and molecular details of an anti-fungal target's interaction with inhibitors suggest ways to design better treatments for fungal infections.

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