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Journal of Biological Chemistry Archives

Scavengers “protect” HDL

Jun. 29, 2018—Lipid molecules that bind to HDL can modify its function — and blocking that modification can protect HDL and potentially lower the risk of atherosclerosis and heart disease.

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Versatile C. difficile blocker

Jan. 26, 2018—New research reveals a unique mechanism of C. difficile toxin neutralization by a monoclonal antibody, suggesting new therapeutic approaches.

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A cataract-heart connection

Jan. 25, 2018—Studies of alpha-B crystallin in zebrafish could ultimately lead to improved treatment for cataracts and heart disease.

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A spicy finding

Jan. 16, 2018—Vanderbilt researchers have discovered that curcumin — the active ingredient in the spice turmeric — needs to be metabolically activated to exert anti-inflammatory effects.

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Forming memories through CaMKII

Dec. 19, 2017—Vanderbilt researchers have identified an interaction between two proteins that play a role in learning and memory.

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DNA damage repair: molecular insights

Dec. 5, 2017—Structural details about a protein involved in the repair of damaged DNA provide insight into xeroderma pigmentosum disorders, which are characterized by increased risk for skin cancer.

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Altered metabolism and disease

Jul. 25, 2017—Vanderbilt researchers report a structure of a human metabolic enzyme bound to its substrate 17alpha-hydroxyprogesterone.

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Fighting fungal infections

Apr. 3, 2017—A detailed structural and functional analysis of the yeast protein that is the main target of antifungal drugs will help direct efforts to develop better treatments.

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Protecting the blood-brain barrier

Dec. 9, 2016—Vanderbilt investigators have discovered how a promising cancer immunotherapy causes brain swelling, findings that could lead to ways to protect brain function while fighting cancers.

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Reducing antidepressants’ side effects

Nov. 23, 2016—Vanderbilt investigators have discovered how antidepressant medicines that block serotonin uptake can increase bleeding risk.

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Building the basement membrane

Nov. 21, 2016—Vanderbilt researchers have discovered steps in the regulation of a key enzyme that builds the basement membrane, a structure that undergirds nearly all animal tissues.

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How strep grabs on to platelets

Apr. 20, 2016—New structural details of the binding of the bacterium Streptococcus sanguinis to platelets may offer new therapeutics for life-threatening cardiovascular infections.

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