Journal Of Biological Chemistry
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Potential protection from atherosclerosis
Vanderbilt researchers have discovered a potential way to reduce atherosclerosis: blocking the modification of an HDL-associated enzyme by reactive molecules called isolevuglandins. Read MoreAug 19, 2021
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New insights into kidney development
Integrin-linked kinase, a central component of a complex that coordinates cell signaling involved in migration, proliferation and cell death, plays a role in kidney development and epithelial cell function. Read MoreApr 15, 2021
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Arrhythmia culprit: supertrafficking ion channel
Charles Sanders, PhD, and colleagues show how a “supertrafficking” mutant potassium channel contributes to heart rhythm abnormalities. Read MoreApr 15, 2021
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New tools to study bioactive lipids
Vanderbilt researchers have identified and characterized inhibitors of an enzyme that synthesizes lipid signaling molecules with roles in energy balance, inflammation and addiction. Read MoreJul 14, 2020
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Staph’s activation of blood clotting
Staph bacteria may change the factor they use to activate blood clotting — to evade the immune response — a new study suggests. Read MoreJun 9, 2020
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A key to calcium signaling
Erkan Karakas and colleagues used cryo-electron microscopy to determine structural details of a calcium channel protein that has numerous cell signaling roles. Read MoreFeb 11, 2020
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A new contributor to atherosclerosis
Sean Davies and colleagues are exploring lipid aldehydes produced during oxidative stress and their contribution to HDL dysfunction and atherosclerosis. Read MoreJan 27, 2020
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A new anti-seizure target?
Vanderbilt neurologists have identified a protein modification that could be targeted to reduce neuronal excitability in epilepsy. Read MoreDec 12, 2019
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How nerves may lose their insulation
Vanderbilt’s Bruce Carter and colleagues have discovered how genetic changes in the protein PMP22 may contribute to a disease of peripheral nerves. Read MoreAug 22, 2019
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Steroid binding to metabolic enzyme
Understanding how a steroid-metabolizing enzyme binds to its substrates may aid in designing drugs to treat sexual dysfunction as well as prostate cancer. Read MoreJun 12, 2019
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Scavengers “protect” HDL
Lipid molecules that bind to HDL can modify its function — and blocking that modification can protect HDL and potentially lower the risk of atherosclerosis and heart disease. Read MoreJun 29, 2018
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Versatile C. difficile blocker
New research reveals a unique mechanism of C. difficile toxin neutralization by a monoclonal antibody, suggesting new therapeutic approaches. Read MoreJan 26, 2018
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A cataract-heart connection
Studies of alpha-B crystallin in zebrafish could ultimately lead to improved treatment for cataracts and heart disease. Read MoreJan 25, 2018
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A spicy finding
Vanderbilt researchers have discovered that curcumin — the active ingredient in the spice turmeric — needs to be metabolically activated to exert anti-inflammatory effects. Read MoreJan 16, 2018
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Forming memories through CaMKII
Vanderbilt researchers have identified an interaction between two proteins that play a role in learning and memory. Read MoreDec 19, 2017
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DNA damage repair: molecular insights
Structural details about a protein involved in the repair of damaged DNA provide insight into xeroderma pigmentosum disorders, which are characterized by increased risk for skin cancer. Read MoreDec 5, 2017
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Altered metabolism and disease
Vanderbilt researchers report a structure of a human metabolic enzyme bound to its substrate 17alpha-hydroxyprogesterone. Read MoreJul 25, 2017
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Fighting fungal infections
A detailed structural and functional analysis of the yeast protein that is the main target of antifungal drugs will help direct efforts to develop better treatments. Read MoreApr 3, 2017
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Protecting the blood-brain barrier
Vanderbilt investigators have discovered how a promising cancer immunotherapy causes brain swelling, findings that could lead to ways to protect brain function while fighting cancers. Read MoreDec 9, 2016
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Reducing antidepressants’ side effects
Vanderbilt investigators have discovered how antidepressant medicines that block serotonin uptake can increase bleeding risk. Read MoreNov 23, 2016