Insulin

Early weight regain after gastric bypass surgery does not reverse metabolic improvements, and the "hunger hormone" ghrelin might indicate who is susceptible to weight regain. Read More

Engineered bacteria that produce a therapeutic compound in the gut prevent obesity in mice, Vanderbilt University investigators have discovered. Read More

In an observational study by researchers at Vanderbilt University Medical Center, adults with type 2 diabetes who take insulin in addition to the recommended first-line drug therapy, metformin, had a 30 percent higher risk of heart attack, stroke or death when compared to similar patients who instead augment their metformin regimen with a sulfonylurea. Read More

The protein CaMKII acts as a calcium sensor in a positive feedback pathway that enhances glucose-stimulated insulin secretion. Read More

A new compound that activates potassium channels could be used to treat disorders of glucose homeostasis. Read More

The extracellular matrix that surrounds cells plays a role in the development of insulin resistance. Read More

It might be possible to generate a “metabolically healthy” state of obesity by targeting signaling pathways that improve insulin sensitivity. Read More

Vanderbilt researchers describe a new technique for identifying factors that stimulate the proliferation of pancreatic beta cells – factors that might offer therapeutic options for diabetes. Read More

The hormone relaxin may offer a novel approach for treating diet-induced insulin resistance. Read More

Gaining and losing weight during “yo-yo dieting” may contribute to an exaggerated immune response in fat tissue that increases metabolic dysfunction more than steady weight gain alone. Read More

A component of the extracellular matrix that surrounds cells plays a role in insulin resistance and may be a good therapeutic target. Read More

Immune cells that recognize self antigens (e.g. insulin), but are functionally silent, can trigger autoimmune diseases such as diabetes. Read More

Diabetes has a big impact on the brain. Read More

A new study finds long-lasting reversal of diabetes is possible without insulin through transplantation of brown fat tissue. Read More

A strain of mutant mice provide a novel model for studying glucose intolerance and gestational diabetes during pregnancy and suggest that certain molecules may be useful for therapeutic applications. Read More

New research into changes in the brains of obese patients and others with substance abuse issues indicate doctors should be more understanding when treating these patients. Read More

A new study is using technology to achieve better control of blood sugar levels early in the the course of type 1 diabetes. Read More