Inflammatory Bowel Disease

The research team includes, left to right, Bruno Scaglioni, PhD; Keith Obstein MD, MPH; James Martin, PhD; Claire Landewee; Simone Calò, PhD; and Pietro Valdastri, PhD. (photo by Susan Urmy) by Jill Clendening A Vanderbilt Institute for Surgery and Engineering (VISE) research team is conducting the first phase 1 clinical trial of a magnetic, flexible... Read More

Gastrointestinal inflammation, such as occurs in inflammatory bowel disease, triggers the expansion of a population of “bone-eating” cells, leading to bone loss. Read More

A novel CRISPR screen developed by Vanderbilt researchers identified a promising new target for anti-inflammatory therapeutics. Read More

A probiotic factor given early in life to mice prevented intestinal inflammation in adulthood, providing a rationale for probiotic intervention in individuals at high risk of developing inflammatory bowel disease. Read More

Vanderbilt investigators demonstrated that intestinal cells promote beneficial microbe behavior — the findings support developing microbiota-based therapies for intestinal health. Read More

Understanding the roles of various immune cells that reside in the gut lining could shed light on inflammatory bowel diseases. Read More

Disruption of the integrity of the intestinal lining or epithelium contributes to a “leaky” gut and is a common feature of patients with inflammatory bowel disease. Yash Choksi, Christopher Williams and colleagues found that low levels of a certain protein exacerbated the condition. Read More

Vanderbilt investigators have developed an algorithm to classify cell types from experimental data, making it possible to understand how organs develop. Read More

Vanderbilt researchers have developed a new optical sensor that can accurately detect different types of inflammatory bowel disease and can be easily integrated into routine colonoscopy exams. Read More

Researchers at Vanderbilt University School of Medicine have uncovered a link between epidermal growth factor receptor (EGFR) signaling and the inflammatory response to bacterial infection in the gastrointestinal tract. Read More

An antioxidant protein may protect against colon cancer that develops in patients with inflammatory bowel disease, suggesting new strategies for reducing colon cancer risk in these patients. Read More

Having a “leaky” gut may protect against colitis, a paradoxical finding that alters understanding of the role of cell permeability in intestinal homeostasis and immune regulation. Read More

The factor STAT6 appears to play a role in the pathogenesis of an inflammatory bowel disease, suggesting it may be a promising target for new treatments. Read More

Berberine, an herbal remedy for diarrhea and intestinal parasites, may be an effective treatment for gastrointestinal inflammatory diseases. Read More