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inflammation Archives

Putting the brakes on sepsis

May. 9, 2018—An enzyme called PTEN reduces inflammatory signaling and mortality in sepsis, suggesting it may be a good therapeutic target for this life-threatening complication of infection.

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A spicy finding

Jan. 16, 2018—Vanderbilt researchers have discovered that curcumin — the active ingredient in the spice turmeric — needs to be metabolically activated to exert anti-inflammatory effects.

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Asthma study may point to potential new therapeutic approach

Jan. 4, 2018—New findings from Vanderbilt suggest that blocking the migration of cells involved in asthma may represent a new approach for treating the respiratory condition.

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Salt, inflammation and hypertension

Nov. 13, 2017—Vanderbilt researchers have identified a pathway that links excess sodium, inflammation and hypertension.

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Bioactive lipids and rheumatoid arthritis

Nov. 1, 2017—An enzyme that produces bioactive fatty acids has elevated activity in patients with rheumatoid arthritis, supporting further studies to understand its biologic roles in the disease.

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A switch for autoimmunity

Oct. 12, 2017—Vanderbilt investigators have discovered a class of compounds that inhibit a mediator of inflammation and autoimmune disorders, and that could pave the way for development of future therapies.

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Flip side of gut protection

Jun. 9, 2017—Vanderbilt investigators report that dysregulation of certain immune cells in the intestines may lead to inflammation and disease.

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A DARPP role in gastric cancer

Nov. 3, 2016—Vanderbilt researchers have discovered a link between Helicobacter pylori infection, inflammation and gastric cancer that could suggest new anti-cancer therapies.

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Going after the ‘heart attack gremlin’

Sep. 8, 2016—A protein called Gremlin 2 controls the extent of inflammation after heart attack and may be a good therapeutic target.

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New treatment for Crohn’s disease

Mar. 22, 2016—A new biological therapy, ustekinumab, improves markers of disease activity in patients with severe Crohn’s disease.

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Eye of a cytokine storm

Mar. 9, 2016—A new animal model can be used to “dissect” the inflammatory response to infection.

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Immune tolerance in endothelial cells

Jan. 7, 2016—Inducing “tolerance” to bacterial toxins in the endothelial cells that line blood vessels may offer a new approach for preventing the negative consequences of sepsis.

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