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Study reveals missing link between high-fat diet, microbiota and heart disease
A high-fat diet disrupts the biology of the gut’s inner lining and its microbial communities — and promotes the production of a metabolite that may contribute to heart disease, according to a study published Aug. 13 in the journal Science. Read MoreAug 12, 2021
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Vitamin D impact on disease biomarkers
In a randomized controlled trial, vitamin D supplementation did not improve biomarkers for cardiovascular and metabolic disease. Read MoreAug 10, 2021
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Sudden death from deep in the brain?
Vanderbilt neurologists found altered excitability in deep brain structures that they note may drive respiratory dysfunction and sudden death in a rare form of epilepsy. Read MoreAug 9, 2021
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Motor protein linked to intestinal cell differentiation
The motor protein MYO5B, a cause of the congenital intestinal disorder microvillus inclusion disease, does more than move cellular cargo, Vanderbilt researchers have discovered. Read MoreAug 5, 2021
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Gene expression in diabetic nephropathy
Vanderbilt researchers are looking to mRNA populations in podocytes — kidney cells that help filter blood — to help identify potential targets for treating diabetic kidney disease. Read MoreAug 5, 2021
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Study finds genetic factor undermines H. pylori treatment
Helicobacter pylori, a stomach-dwelling bacterium, is a strong risk factor for gastric cancer, peptic ulcers and other debilitating gastrointestinal disorders. Read MoreAug 4, 2021
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Discovery points to new avenues to kill aggressive cancer cells
Chemoresistant SW480 colon cancer cells stained for lipid rafts (green), death receptor 4 (red) and cell nuclei (blue). Image taken by Joshua Greenlee using a Zeiss LSM 880 from the Vanderbilt Cell Imaging Shared Resource Center. By Marissa Shapiro THE IDEA Vanderbilt faculty and researchers are looking for the “Achilles’ heel” of the cancer cells... Read MoreAug 3, 2021
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Discovery points to new avenues to kill aggressive cancer cells
Chemoresistant SW480 colon cancer cells stained for lipid rafts (green), death receptor 4 (red) and cell nuclei (blue). Image taken by Joshua Greenlee using a Zeiss LSM 880 from the Vanderbilt Cell Imaging Shared Resource Center. By Marissa Shapiro THE IDEA Vanderbilt faculty and researchers are looking for the “Achilles’ heel” of the cancer cells... Read MoreAug 3, 2021
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Prediction models for breast cancer
Vanderbilt researchers developed new prognostic models for breast cancer outcomes and found that adding postdiagnostic weight change as a factor improves the prediction. Read MoreJul 27, 2021
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NSF virtual expo this week highlights 3 major projects led by VUSE faculty
Three ambitious, multidisciplinary projects led by Vanderbilt School of Engineering faculty will be featured Wednesday and Thursday, July 28 and 29, during the NSF Convergence Accelerator Expo 2021. The two-day virtual event will present 15-minute demonstrations of novel solutions that address big-scale societal challenges. The NSF-funded projects integrate disciplines and include industry partners from their... Read MoreJul 26, 2021
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Mood and cognition after chemotherapy
Validation of cognitive complaints appears to improve mood in patients with persistent chemotherapy-cognitive impairment, Vanderbilt researchers report. Read MoreJul 26, 2021
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For more precise drug treatments, ‘squeeze’ the genome: study finds
Large-scale studies will be required to identify the complexity of genetic variations that affect how patients respond to a given drug and whether they will have side effects, according to researchers at Vanderbilt University Medical Center. Read MoreJul 22, 2021
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Influenza network sizes up COVID
Hospital data from a CDC network that monitors influenza revealed that adults hospitalized for COVID-19 in the early months of the pandemic were 20x more likely to die compared to hospitalized influenza patients. Read MoreJul 22, 2021
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Team wins competitive DOE award to advance isotope production critical for U.S. science, medicine and industry
A U.S. Department of Energy $4 million initiative to advance research in isotope production includes a Vanderbilt engineering professor’s work on separation technologies and to scale up processes. The funding is part of a key federal program that produces critical isotopes otherwise unavailable or in short supply for U.S. science, medicine and industry. Piran Kidambi,... Read MoreJul 22, 2021
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Team wins competitive DOE award to advance isotope production critical for U.S. science, medicine and industry
A U.S. Department of Energy $4 million initiative to advance research in isotope production includes a Vanderbilt engineering professor’s work on separation technologies and to scale up processes. The funding is part of a key federal program that produces critical isotopes otherwise unavailable or in short supply for U.S. science, medicine and industry. Piran Kidambi,... Read MoreJul 22, 2021
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$1.5M DOE grant targets engineering of cyanobacteria as biofuel production platform
A new, $1.5 million Department of Energy grant brings together experts from three institutions to parse the metabolism of a blue-green algae that holds great promise for biofuel production. The team, led by Professor of Chemical and Biomolecular Engineering Jamey Young, will take a systems biology approach to identify how cyanobacteria, also known as blue-green... Read MoreJul 20, 2021
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$1.5M DOE grant targets engineering of cyanobacteria as biofuel production platform
A new, $1.5 million Department of Energy grant brings together experts from three institutions to parse the metabolism of a blue-green algae that holds great promise for biofuel production. The team, led by Professor of Chemical and Biomolecular Engineering Jamey Young, will take a systems biology approach to identify how cyanobacteria, also known as blue-green... Read MoreJul 20, 2021
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Drug allergy labels in medical records power searches for gene-drug associations
2.2 million patients admitted to U.S. hospitals in 1994 were either admitted due to a serious adverse drug reaction or had a serious ADR while in the hospital. With BioVU, researchers are conducting a retrospective scan for information that confer risk of an ADR involves a search for exposures to the drug of interest and natural language processing of clinical notes to sort out normal and abnormal drug responses. Read MoreJul 17, 2021
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CS student’s Microsoft dissertation grant supports her vision disability research
Computer science graduate student Haley A. Adams has been awarded a 2021 Microsoft Research Dissertation Grant. She is one of 10 recipients in the United States and Canada who are underrepresented in the field of computing and pursuing research aligned to research areas carried out by Microsoft researchers. Microsoft aims to increase the pipeline of... Read MoreJul 16, 2021
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Arterial stiffening linked to Alzheimer’s disease
A research team from Vanderbilt University Medical Center reports in Neurology that greater stiffening of the aorta, the main artery in the human body, is associated in older adults with increased Alzheimer’s disease (AD) pathology as reflected in a ra... Read MoreJul 15, 2021