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drug resistance Archives

Researchers find novel mechanism of resistance to anti-cancer drugs

Oct. 17, 2017—Vanderbilt investigators have discovered a novel non-genetic cause of resistance to the targeted anti-cancer therapy cetuximab. Their findings, reported this week in Nature Medicine, suggest a strategy for overcoming this resistance.

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Reporter


New test rapidly identifies cause of blood infections

May. 4, 2017—Last month, Vanderbilt Clinical Laboratories introduced rapid molecular diagnostic testing to more quickly identify microorganisms that may be causing a patient’s bloodstream infection, along with the organism’s susceptibility to drugs.

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Reporter


Overcoming lung cancer drug resistance

Feb. 10, 2016—Vanderbilt investigators have discovered a way to overcome the resistance of some lung cancers to certain targeted therapies, which could lead to more effective treatments for lung cancer patients.

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Health and Medicine Reporter Research


Dynamics of a drug resistance transporter

Feb. 5, 2016—Vanderbilt investigators are exploring the shape changes in a multidrug transporter to understand the mechanisms of antibacterial resistance.

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Health and Medicine Reporter Research


New lead for ovarian cancer treatment

Dec. 10, 2015—Combining inhibitors of the BMP signaling pathway with standard chemotherapy drugs may overcome drug resistance in ovarian cancer.

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Health and Medicine Reporter Research


Detect and defend against pathogens

Nov. 4, 2015—Understanding factors, such as the receptor TLR9, that detect and defend against pathogens may lead to therapeutic approaches that promote an effective immune response to treat infections.

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Health and Medicine Reporter Research


Targeting HIV’s “cap”

Feb. 10, 2015—New findings underscore the attractiveness of the HIV capsid – the structure that encloses the viral genome – as a therapeutic target.

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Health and Medicine Reporter Research


Key to prostate cancer resistance

Oct. 29, 2014—A combination of two types of therapy may be more effective in treating castration-resistant prostate cancer.

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Health and Medicine Reporter Research


How ABC transporters move molecules

Jun. 13, 2014—New views of how transporters move molecules across cell membranes are key to understanding how these proteins impact tumor cell drug resistance and inherited diseases such as cystic fibrosis.

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Health and Medicine Reporter Research


Dismantling staph’s drug resistance

Mar. 3, 2014—Targeting the enzyme FosB could make antibiotic-resistant staph bacteria sensitive to the antibiotic fosfomycin.

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Health and Medicine Reporter Research


Proton transfer powers multidrug resistance: study

Dec. 12, 2013—Vanderbilt University researchers and their Belgian colleagues have discovered the mechanism behind a multidrug transporter. Their findings, posted this week by Nature Chemical Biology, could lead to new treatments for multidrug resistant bacterial infections.

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Health and Medicine Reporter Research


VU study identifies DNA changes in drug-resistant cancer cells

Sep. 12, 2013—Vanderbilt investigators have combined next-generation sequencing technologies and bioinformatics analyses to screen for genome-wide genetic mutations associated with drug resistance in a series of lung cancer cell lines.

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Health and Medicine Reporter Research


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