Drug Development
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Rethinking drug efficacy: research aims to improve drug development
ASPIRE to Innovate Postdoctoral Fellow Catherine Leasure is the co-author of a comment article published this month in Nature Reviews Bioengineering addressing the pressing obstacle faced by modern drug development: worryingly poor success rates of pharmaceuticals progressing to clinical phases. Read MoreMar 1, 2024
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Merryman, Lindsley make headway in drug development to cure pulmonary arterial hypertension
Research led by David Merryman, a professor of biomedical engineering, pharmacology and medicine who holds the Walters Family Chair, has resulted in the development of VU6047534, a new drug that treats pulmonary arterial hypertension—a type of high blood pressure that affects arteries in the lungs and in the heart—without serious neurological side effects. Merryman conducted... Read MoreSep 13, 2023
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Ancora inaugural request for proposals announced
The Office of the Vice Provost for Research and Deerfield Management announce the inaugural request for proposals for Ancora Innovation, LLC, with a due date of June 4. An RFP information session is scheduled from 2 to 3:30 p.m. Friday, April 27, at Sarratt Student Center, Room 325. Read MoreApr 20, 2018
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Regulating anxiety in the brain
Two brain signaling pathways have overlapping functions in regulating anxiety, suggesting that therapeutics aimed at one or the other will impact both. Read MoreApr 28, 2017
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Protein structure may aid in treating Alzheimer’s disease
A new protein structure may guide the development of Alzheimer's therapeutics. Read MoreApr 27, 2017
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New type of trial shows promise for several cancers
Anti-cancer drugs are typically tested on one type of cancer at a time. But an international consortium of cancer investigators, including Vanderbilt-Ingram Cancer Center (VICC) researchers, simultaneously tested an existing therapy in patients with several different forms of cancer that all exhibit the same tumor gene mutation. Read MoreAug 20, 2015
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Significant progress toward creating “benchtop human” reported
Vanderbilt physicist John Wikswo reported significant progress toward creating “homo minutus” – a human-on-a-chip that can be used to test drugs and toxins – on Mar. 26 at the Society of Toxicology meeting in Phoenix. Read MoreMar 27, 2014