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DNA repair Archives

DNA damage repair: molecular insights

Dec. 5, 2017—Structural details about a protein involved in the repair of damaged DNA provide insight into xeroderma pigmentosum disorders, which are characterized by increased risk for skin cancer.

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Health and Medicine Reporter Research


Deciphering potent DNA toxin’s secrets

Aug. 1, 2017—Vanderbilt researchers uncover the secret of the remarkable potency of the DNA toxin yatakemycin, which could someday be harnessed to fight cancer.

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Life, Earth and Space Research


A new mode of DNA repair

Apr. 14, 2017—Structural details of a protein that removes DNA lesions shed light on fundamental mechanisms of DNA repair.

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Health and Medicine Reporter Research


Mechanism of a DNA repair protein

Apr. 15, 2016—Vanderbilt investigators have discovered details about the mechanism of an important DNA repair protein that maintains genome stability.

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Health and Medicine Reporter Research


Copying chromosome caps

Jan. 8, 2016—Telomeres – the caps on the end of chromosomes – are a source of stress for a particular protein involved in copying DNA, a new study reports.

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Health and Medicine Reporter Research


Study helps clarify components of DNA ‘copy machine’

Nov. 12, 2015—Vanderbilt investigators have generated a “parts list” for the molecular machinery that duplicates DNA each time a cell divides. The research has implications for cancer therapies that target components of this machinery.

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Health and Medicine Reporter Research


Study reveals how protein helps cells tolerate DNA damage

Jul. 16, 2015—Vanderbilt and Stanford investigators have discovered how a protein that's part of the DNA replication "machinery" helps cells tolerate DNA damage.

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Health and Medicine Reporter Research


Repair protein’s DNA recognition motif

May. 23, 2014—Insights into the workings of DNA damage response proteins such as SMARCAL1 could suggest new ways to improve genome integrity and prevent cancer.

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Health and Medicine Reporter Research


Bypassing DNA damage

May. 9, 2014—Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage.

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Health and Medicine Reporter Research


VU study sheds new light on DNA replication

Nov. 7, 2013—David Cortez, Ph.D., and his Vanderbilt colleagues report new findings that shed light on fundamental processes involved in DNA replication and have implications for cancer therapies that target these processes.

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Health and Medicine Reporter Research


iPOND method goes fishing for proteins

Mar. 19, 2012—A new tool will allow researchers to identify proteins involved in DNA replication and damage repair, processes that go awry in cancer.

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Health and Medicine Reporter Research