Department Of Pediatrics
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Study finds Moderna’s COVID-19 vaccine safe and effective for young children
A Vanderbilt study finds that Moderna’s COVID-19 vaccine is safe and effective in children 6 months to 5 years of age. Read MoreNov 4, 2022
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Vanderbilt researchers discover how gut inflammation leads to bone loss
Gastrointestinal inflammation, such as occurs in inflammatory bowel disease, triggers the expansion of a population of “bone-eating” cells, leading to bone loss. Read MoreAug 25, 2022
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VUMC-led study finds Moderna COVID vaccine safe and effective for children
Moderna’s COVID-19 vaccine is safe and generates robust immune responses in children ages 6 to 11 years, a national clinical trial co-led by C. Buddy Creech, MD, MPH, has found. Read MoreMay 12, 2022
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High blood pressure genes improve heart surgery survival in children
Vanderbilt researchers have found that children with a genetic makeup that predicts high blood pressure as adults are more likely to survive congenital heart defect repair surgery. Read MoreMar 24, 2022
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Study identifies molecular trigger of severe injury-induced inflammatory response
Vanderbilt researchers have discovered that early inappropriate activation of the enzyme plasmin caused by severe injury is a trigger of systemic inflammatory response syndrome and resulting organ failure. Read MoreJan 19, 2022
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“Atlas” of lung development may aid efforts to heal premature lungs
Researchers at Vanderbilt University Medical Center have constructed a single-cell “atlas” of lung development that tracks multiple cell types over time. Read MoreDec 20, 2021
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International study supports dupilumab for treatment of moderate-to-severe asthma in children
In a late-stage clinical trial, the biologic agent dupilumab reduced the rate of severe asthma attacks and improved lung function and asthma control for children ages 6 to 11 with moderate-to-severe asthma, offering a new option to these patients. Read MoreDec 8, 2021
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‘Pre-conditioning’ restores immune tolerance
A treatment targeting T-cell metabolism could reinvigorate immune tolerance mechanisms to combat autoimmune disease and transplant rejection, Vanderbilt researchers discovered. Read MoreSep 16, 2021
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For more precise drug treatments, ‘squeeze’ the genome: study finds
Large-scale studies will be required to identify the complexity of genetic variations that affect how patients respond to a given drug and whether they will have side effects, according to researchers at Vanderbilt University Medical Center. Read MoreJul 22, 2021
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Gene variant linked to unnecessary bone marrow biopsies in African Americans
A gene variant that lowers white blood cell levels and is common in individuals with African ancestry contributes to unnecessary bone marrow biopsies, according to a study published June 28 in JAMA Internal Medicine. The findings, led by investigators at VUMC, are an example of how using genetic data could reduce a health disparity. Read MoreJun 28, 2021
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Therapeutic antibodies for hantavirus
Vanderbilt Vaccine Center researchers have isolated monoclonal antibodies against hantaviruses, an emerging source of human disease with pandemic potential. Read MoreMay 24, 2021
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New clue to lung scarring
Vanderbilt neonatology team pinpoints signaling pathways involved in the progressive lung fibrosis that occurs in rare genetic diseases. Read MoreMay 20, 2021
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Novel way to neutralize Rift Valley Fever Virus
The discovery of monoclonal antibodies that neutralize Rift Valley Fever Virus — an emerging infection with pandemic potential — lays the foundation for future therapeutic antibody development. Read MoreApr 1, 2021
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Probiotic protection
A probiotic factor given early in life to mice prevented intestinal inflammation in adulthood, providing a rationale for probiotic intervention in individuals at high risk of developing inflammatory bowel disease. Read MoreMar 4, 2021
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Calcification after severe injury
Vanderbilt researchers have linked bone-related complications of severely injured patients — findings that could help minimize these complications. Read MoreFeb 23, 2021
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An interacting factor in leukemia
A blood stem cell protein plays a role in the initiation and progression of leukemia, Vanderbilt researchers have found. Read MoreJan 25, 2021
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Fleming, professor of pediatrics and vice president of VUMC Continuous Professional Development, has died
Geoffrey Fleming, professor of pediatrics in the Division of Pediatric Critical Care Medicine and vice president of Vanderbilt University Medical Center Continuous Professional Development, died Dec. 8. He was 50. Fleming was diagnosed with metastatic cholangiocarcinoma in August 2019. Read MoreDec 10, 2020
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Exploiting viral vulnerabilities
The isolation of human monoclonal antibodies against dangerous viruses including EEEV, Hendra and Nipah could offer new ways to treat and prevent these infections. Read MoreDec 10, 2020
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New treatment for a rare obesity
Diabetes drugs known as GLP-1 receptor agonists, such as exenatide (Byetta), are a promising and safe treatment for a rare form of obesity. Read MoreNov 3, 2020
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Early steps in reovirus replication
Conformational change in a reovirus surface protein modulate the virus’s attachment to host cells, Vanderbilt researchers have found. Read MoreOct 6, 2020