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Department of Medicine Archives

Protein interaction protects against neurodegeneration

Sep. 2, 2014—Two proteins interact to maintain selenium levels in the brain, and protect neurons from degeneration.

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Study finds coronary arteries hold heart-regenerating cells

Aug. 20, 2014—Endothelial cells residing in the coronary arteries can function as cardiac stem cells to produce new heart muscle tissue, Vanderbilt University investigators have discovered.

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Novel treatment strengthens bones in genetic disease

Aug. 7, 2014—An enzyme therapy may prevent skeletal abnormalities associated with the genetic disorder neurofibromatosis type-1, Vanderbilt investigators have discovered.

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Low selenium and lung cancer

Aug. 6, 2014—Vanderbilt researchers have found that selenium deficiency may contribute to the racial disparity in lung cancer incidence.

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Anti-inflammatory protein “rheostat” sheds light on leaky blood vessels

Aug. 1, 2014—Vanderbilt researchers have discovered that the protein CRADD counteracts inflammatory injury to endothelial cells, which could assist the development of new therapies for inflammatory vascular disorders.

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Molecular ‘chat’ holds kidney fibrosis clues

Jul. 10, 2014—A novel molecular “conversation” regulates kidney fibrosis – the final result of end-stage chronic kidney disease – suggesting new treatment options for this currently irreversible process.

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Normalizing calcium flux to treat atrial fibrillation

May. 12, 2014—A particular anti-arrhythmia drug provides a targeted treatment for certain forms of atrial fibrillation.

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Potential mechanism for myeloma drug’s variable toxicity

Apr. 30, 2014—A genetic variant is associated with toxicity of the chemotherapy drug melphalan, and could guide individualized dosing for the medication.

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Increased cell permeability may protect from colitis

Apr. 25, 2014—Having a “leaky” gut may protect against colitis, a paradoxical finding that alters understanding of the role of cell permeability in intestinal homeostasis and immune regulation.

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Dugan named to lead Division of Geriatric Medicine

Apr. 3, 2014—Laura Dugan, M.D., the Larry L. Hillblom Chair in Geriatric Medicine at the University of California San Diego (UCSD), will join the Vanderbilt faculty on April 7 to direct Vanderbilt University’s Division of Geriatric Medicine, a division of the Department of Medicine.

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Study links stem cell gene to prostate cancer susceptibility

Mar. 27, 2014—A gene on chromosome 8 — in a region of the genome linked to risk for many types of cancer — is particularly associated with prostate cancer susceptibility, Vanderbilt University researchers have found.

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Delirium increases long-term disability

Mar. 17, 2014—Patients who suffer a longer duration of delirium in the intensive care unit are more likely to experience long-term disability after discharge.

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