Department Of Medicine

Idiopathic subglottic stenosis is an unexplained narrowing of the windpipe just below the vocal cords. The disease is progressive, slowly affecting the patient’s ability to breathe, and can be fatal due to airway obstruction if left untreated. Read More

More than half of patients with relapsed multiple myeloma treated with carfilzomib experienced cardiac issues during treatment, according to a multi-institutional study published June 12 in the Journal of Clinical Oncology. Read More

Microbial species in the mouth could be playing a role in colorectal cancer development, according to new research from epidemiologists at VUMC. Read More

Timothy Cover, john Loh and colleagues have identified how a certain type of mutation influences the risk of premalignant and malignant changes in the stomach. Read More

Craig Brooks and colleagues have identified a mechanism of kidney fibrosis progression, suggesting a potential new angle for treating chronic kidney disease. Read More

Exposure to antibiotics during pregnancy does not raise the risk of obesity in children. Read More

Craig Lindsley, co-director of the Vanderbilt Center for Neuroscience Drug Discovery, has been named a fellow of the National Academy of Inventors. Read More

The grant will support Mary Philip's research to develop an organoid model — a miniature cell model of a functioning organ — of the liver to enable three-dimensional observation of immune-cancer interactions at the single-cell level at the earliest stages of cancer development. Read More

In the first large-scale analysis of cardiovascular complications linked to immune checkpoint inhibitors, Vanderbilt researchers have identified several of the conditions that arise and have determined that they usually appear early in treatment. Read More

A new link between a support protein within the brain's white matter and known Alzheimer's biomarkers discovered by Angela Jefferson and colleagues bring researchers a step toward earlier and more precise detection of neuropathology underlying cognitive impairment that may lead to new targeted therapies Read More

Loss of a protein that regulates mitochondrial function can greatly increase the risk of a heart attack, report Eric Gamazon, Sandra Zinkel and graduate students Christie Salisbury-Ruf and Clinton Bertram in new research. Read More

New research by David Harrison and colleagues sheds light on how changes in mechanical forces in the aorta enhance immune cell activation thus promoting hypertension. Read More

An international team led by researchers at Vanderbilt University Medical Center sheds new light on the cause of pulmonary fibrosis and demonstrates a way to impede the disease. Read More

A trans-institutional team of researchers at Vanderbilt University Medical Center and Vanderbilt University has received an $11 million Cancer Moonshot grant to build a single-cell resolution atlas to map out the routes that benign colonic polyps take to progress to colorectal cancer, the third most common cancer among both men and women in the United States. Read More

A new study by Harvey Murff finds that diabetics who take metformin have lower rates of liver cancer than those who take other diabetes drugs. Read More

Stephen Deppen and colleagues have developed an updated map showing new areas of increased risk for a common lung infection. Read More

Researchers led by melanoma researcher Douglas Johnson have answered questions about the incidence and timing of rare but sometimes fatal reactions to the most widely prescribed class of immunotherapies. Read More

An immune cell called CD8+ is supposed to attack disease, but it can also contribute to inflammation, which can lead to insulin resistance and type 2 diabetes. Read More

Vanderbilt researchers have discovered new insights into the treatment of chronic graft-versus-host-disease, a complication of bone marrow and stem cell transplants. Read More

Xiangming Ji, Pierre Massion and colleagues have discovered that blocking the transporter protein xCT could slow the progression of non-small cell lung cancer. Read More