Department Of Medicine

A single pill containing low doses of three medications to treat high blood pressure and one to lower cholesterol reduced the estimated risk of cardiovascular disease by 25%, according to a VUMC study. Read More

Vanderbilt researchers have discovered that a protein called SGK1 in immune cells is activated by sodium, leading to the development of salt-sensitive hypertension. Read More

Gene variants associated with cancer risk appear to contribute to carcinogenesis by regulating target genes that in turn promote the generation of mutations. Read More

Vanderbilt investigators demonstrated that intestinal cells promote beneficial microbe behavior — the findings support developing microbiota-based therapies for intestinal health. Read More

A previously unrecognized role for a cell surface receptor may open new therapeutic options for the treatment of fibrotic diseases. Read More

Michael Savona, MD, has received a competitive grant to develop therapies for patients with myelodysplastic syndromes. Read More

A national study is seeking to determine whether genetic testing can help physicians choose the best drugs for their patients to relieve pain and depression. Read More

Men are more susceptible to progressive kidney disease than women; new VUMC studies point to differences in the expression and activation of the EGF receptor. Read More

Researchers are chronicling rare but serious toxicities that may occur with immune checkpoint inhibitors, the most widely prescribed class of immunotherapies. Read More

Meena Madhur, MD, PhD, has received a Presidential Early Career Award for Scientists and Engineers. Read More

A new imaging method makes it possible to directly measure cell division and changes in metabolism in atherosclerotic plaques. Read More

Biomarkers of DNA methylation, which regulate gene expression, can be a predictor of breast cancer risk. Read More

Fish oil supplementation provides a modest but beneficial effect on reducing molecules associated with colorectal cancer development. Read More

Vanderbilt researchers have discovered that the gut microbiome composition modulates how dietary nutrients are metabolized, with potential downstream consequences on metabolic health. Read More

A study published June 17 in Nature offers clues as to why blocking inhibitory receptors on tumor-infiltrating T cells may not always work Read More

Idiopathic subglottic stenosis is an unexplained narrowing of the windpipe just below the vocal cords. The disease is progressive, slowly affecting the patient’s ability to breathe, and can be fatal due to airway obstruction if left untreated. Read More

More than half of patients with relapsed multiple myeloma treated with carfilzomib experienced cardiac issues during treatment, according to a multi-institutional study published June 12 in the Journal of Clinical Oncology. Read More

Microbial species in the mouth could be playing a role in colorectal cancer development, according to new research from epidemiologists at VUMC. Read More

Timothy Cover, john Loh and colleagues have identified how a certain type of mutation influences the risk of premalignant and malignant changes in the stomach. Read More

Craig Brooks and colleagues have identified a mechanism of kidney fibrosis progression, suggesting a potential new angle for treating chronic kidney disease. Read More