Cystic Fibrosis
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Researchers develop robotic sensory cilia that monitor internal biomarkers to detect and assess airway diseases
Vanderbilt engineering professor Xiaoguang Dong is leading a team of researchers that has developed a system of artificial cilia capable of monitoring mucus conditions in human airways to better detect infection, airway obstruction, or the severity of diseases like cystic fibrosis, chronic obstructive pulmonary diseases and lung cancer. Read MoreNov 7, 2024
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New collaborative research project seeks improved treatment for cystic fibrosis
Lars Plate, assistant professor of chemistry and biological sciences, has received a $2.76 million collaborative grant to investigate medical therapy for people with cystic fibrosis. The interdisciplinary project brings together teams with varied expertise in computational structural biology, proteomics, biophysics, and physiology in hopes of improving the quality of life for those afflicted with the genetic disease. Read MoreNov 16, 2023
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EHRs, biobanks and Mendelian diseases
Electronic health records and biobanks can be effectively combined to detect and study Mendelian diseases such as cystic fibrosis. Read MoreApr 30, 2020
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VUMC investigators find pathogens work together to infect host
Pseudomonas aeruginosa and Staphylococcus aureus — two pathogens that frequently co-infect the lungs of patients with cystic fibrosis — appear to cooperate with each other, Vanderbilt investigators have discovered. When pseudomonas is starved for metal by the host, it shuts down the production of factors that would normally kill staph, promoting a co-infection. Read MoreNov 3, 2016
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Study reveals new clues to cystic fibrosis ‘gender gap’
A research team led by structural biologists from Vanderbilt University has come up with the first detailed molecular explanation for a factor that may contribute to the so-called cystic fibrosis (CF) “gender gap.” Read MoreSep 15, 2016
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Through Sara’s Eyes: Creating a Legacy Rich in Possibilities for Future Students
As parents we were proud of Sara’s curiosity, boldness, openness to new experiences and thirst for life. And we were even more proud of the woman who returned to us from France after her junior year, more self-confident and aware of the world around her. Read MoreMar 23, 2015
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How ABC transporters move molecules
New views of how transporters move molecules across cell membranes are key to understanding how these proteins impact tumor cell drug resistance and inherited diseases such as cystic fibrosis. Read MoreJun 13, 2014
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Reversing lipid woes in cystic fibrosis
Abnormal levels of fatty acids in the blood and tissues of patients with cystic fibrosis may be reversed by supplementation with the fatty acids DHA and EPA. Read MoreMar 3, 2012