Cancer Biology
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Dual-action enzyme protects esophagus
An antioxidant enzyme also functions as a tumor suppressor to limit cancer development in the esophagus. Read MoreMay 9, 2013
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Leukemia culprit’s cellular actions
Overexpression of a gene that is a common culprit in leukemia induces stem cell-like features in T cells, which may enable the cells to become cancerous. Read MoreApr 11, 2013
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Nobel laureate Hartwell set for Discovery Lecture
Nobel laureate Lee Hartwell, Ph.D., will deliver the next Flexner Discovery Lecture on Thursday, April 11. Read MoreApr 4, 2013
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Foundation lauds graduate student’s melanoma research
Katherine Hutchinson, a third-year graduate student in Cancer Biology at Vanderbilt University, has won a $10,000 Research Scholar Award from the Joanna M. Nicolay Melanoma Foundation. Read MoreMar 28, 2013
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New drugs a good BET for brain cancer
A novel class of drugs that target “BET” proteins may have broad utility for treating genetically diverse brain tumors. Read MoreMar 20, 2013
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Linking oxygen, iron and red blood cells
The HIF oxygen-sensing pathway and its responses to low oxygen may be targeted for treatments of anemia and disorders of iron balance. Read MoreFeb 6, 2013
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Brain tumor TIP reveals new target
The protein TIP-1 appears to be a novel prognostic marker for glioblastoma and may be a good therapeutic target for disrupting tumor-driven blood vessel development. Read MoreFeb 4, 2013
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Do-it-yourself repair in the kidney
The kidney can mediate its own repair through proliferation of resident immune system cells. Read MoreJan 31, 2013
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A drug combo for ovarian cancer
Combining another drug with platinum-based chemotherapies may be more effective against ovarian cancer. Read MoreDec 24, 2012
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Study tracks antioxidants’ role in prostate tumor growth
Antioxidants promote cell growth in a mouse model of prostate cancer, Vanderbilt researchers report in the journal PLoS ONE. The findings provide insight into the recent controversy regarding antioxidants and prostate cancer prevention. Read MoreNov 15, 2012
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Stomach bug alters tumor suppressor
The stomach bug Helicobacter pylori increases forms of a protein that promote tumor development, perhaps explaining how it elevates risk for gastric cancer. Read MoreOct 23, 2012
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Proteins help flip tumor’s invasive switch
Vanderbilt investigators have identified how two key components of cancer's invasive "switch" — the series of signaling events that turn on a tumor cell’s invasive behavior — work together. Read MoreOct 4, 2012
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Target acquired for aggressive tumor
New therapeutic target for angiosarcoma – an aggressive, highly fatal tumor of the blood vessels – identified. Read MoreSep 27, 2012
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Cells with LIP eat their neighbors
A transcription factor called LIP is capable of causing one cell to consume another. Read MoreSep 13, 2012
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Enzyme counters stomach acid attack
Dysfunction or loss of an “antioxidant” enzyme may lead to higher risk for esophageal cancer in patients with gastric reflux disease. Read MoreSep 11, 2012
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Gene linked to familial prostate cancer
A rare, inherited mutation confers an eightfold increased risk of prostate cancer, a recent study shows. Read MoreAug 23, 2012
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Network approach yields glioblastoma clues
MicroRNA “regulatory networks” generated at Vanderbilt aid search for biomarkers and new drugs to treat glioblastoma, the most common and lethal primary brain tumor. Read MoreAug 9, 2012
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On the hunt for bladder cancer factors
A protein linked to aggressive bladder cancers could point to new strategies for treatment or prevention. Read MoreJul 26, 2012
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Proteins guard against cancer spread
Targeting immune system proteins may keep prostate cancer from spreading to bone. Read MoreJul 24, 2012
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VU study finds stress fuels breast cancer metastasis to bone
Stress can promote breast cancer cell colonization of bone, Vanderbilt Center for Bone Biology investigators have discovered. Read MoreJul 18, 2012