BRAF
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Interdisciplinary melanoma research brings understanding of cellular resistance to cancer treatment, opening doors to new cures
Drug-tolerant persister cells–those that survive cancer treatment–found to rely on similar survival mechanisms across cancers, in a groundbreaking study led by Vanderbilt researchers. Read MoreOct 21, 2020
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“Idling” cancer cells may return
Vanderbilt investigators have discovered that cancer treatment induces an “idling” state for cells, which could promote resistance to treatment. Read MoreApr 11, 2018
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PET imaging to predict tumor response
A PET probe that detects the amino acid glutamine predicts whether tumors respond to certain targeted therapies in preclinical animal models. Read MoreJun 14, 2017
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Investigators find clues to melanoma treatment resistance
Nearly half of all patients with malignant melanoma, the most deadly form of skin cancer, have a mutation in the BRAF gene found in their tumors. Mutations in the BRAF gene turn on a cancer growth switch known as the MAP kinase pathway. Read MoreOct 29, 2015
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Combined drug therapy may delay melanoma progression
Combination therapy with two drugs delayed the development of treatment resistance in patients with metastatic melanoma that expresses a specific mutation in the BRAF gene. Read MoreOct 25, 2012
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Study finds mutation in melanoma sensitive to drug
An uncommon mutation of the BRAF gene in melanoma patients has been found to respond to a specific drug therapy, providing a rationale for routine screening and therapy in melanoma patients who harbor the BRAF L597 mutation. Read MoreJul 26, 2012
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New drug mutes more melanomas
An experimental melanoma drug may be beneficial for patients not eligible for targeted therapies. Read MoreApr 26, 2012
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Risk of secondary tumors from melanoma drug studied
A new study offers clues on why melanoma patients who are treated with oral drugs inhibiting the BRAF gene are at increased risk for developing secondary skin cancers. Read MoreMar 23, 2012
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New melanoma drug nearly doubles survival in majority of patients
Investigators from Vanderbilt-Ingram Cancer Center and 12 other centers in the United States and Australia have found that a new drug for patients with metastatic melanoma nearly doubled median overall survival. Read MoreFeb 23, 2012