Bone
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Bone matrix changes during aging
Changes to the bone matrix that occur during aging may point to novel targets for treating osteoporosis. Read MoreJan 10, 2020
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Stress may switch on bone “mets”
New findings could explain the link between chronic stress and reduced survival in women diagnosed with breast cancer, and could lead to new strategies to improve treatment outcomes. Read MoreAug 9, 2017
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Unal receives Orthopedic Research Society award
Mustafa Unal, Ph.D., a postdoctoral research fellow at Vanderbilt University School of Medicine, has been selected by the Orthopedic Research Society to receive its 2017 Alice L. Jee Young Investigator Award for work that potentially will improve the clinical assessment of bone strength and quality. Read MoreJun 15, 2017
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Plasmin prevents muscle ‘hardening’ after injury: study
Vanderbilt researchers have made the surprising discovery that the protease plasmin, known for its clot-busting role in the blood, protects soft tissue from turning to bone after severe injuries and certain orthopaedic surgeries. Read MoreDec 8, 2016
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Neurofibromin fine-tunes bone growth
The protein neurofibromin acts as a brake in a signaling pathway that is important in bone development, Vanderbilt researchers have discovered. Read MoreMay 6, 2015
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Inner ear keeps bones strong
Alterations of the vestibular system - the part of our inner ear that controls balance - may contribute to bone loss related to both aging and space travel. Read MoreJan 14, 2015
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Novel treatment strengthens bones in genetic disease
An enzyme therapy may prevent skeletal abnormalities associated with the genetic disorder neurofibromatosis type-1, Vanderbilt investigators have discovered. Read MoreAug 7, 2014
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Factor impacts bone toughness
The factor ATF4 has a role in the toughness of bone and its resistance to fracture, suggesting new therapeutic targets. Read MoreJun 16, 2014
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Neurotransmitter’s role in bone balance
Removal of the neurotransmitter norepinephrine from the space outside cells plays an important role in the regulation of bone remodeling. Read MoreNov 7, 2013
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Factor’s role in long bone development
Insight into how the protein neurofibromin participates in the signaling pathway that produces the body’s long bones has implications for fracture healing in some patients. Read MoreJul 31, 2013
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Inner ear’s role in bone remodeling
The inner ear system that senses gravity and movement plays a role in bone remodeling – a finding that has clinical implications for space travel and for patients with inner ear disorders. Read MoreMay 15, 2013
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‘Longevity’ gene has role in bone loss
A gene associated with long life participates in the normal regulation of bone remodeling and may have a role in bone loss associated with aging. Read MoreDec 6, 2012
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VU study finds stress fuels breast cancer metastasis to bone
Stress can promote breast cancer cell colonization of bone, Vanderbilt Center for Bone Biology investigators have discovered. Read MoreJul 18, 2012
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A better picture of bone strength
A component of some MRI scans reveals that "soft" components, like collagen and collagen-bound water, are important players in bone strength. Read MoreMar 2, 2011