Aliquots

New details about the life cycle of respiratory syncytial virus (RSV) could aid the development of therapies to combat this leading cause of serious illness in infants and the elderly. Read More

ResearchMatch.org is a web-based registry that is connecting participants and researchers for clinical studies. Read More

A new analytical tool points to genes that act together to increase disease risk. Read More

Treatment with a drug used to prevent organ rejection partially reverses the course of tuberous sclerosis, research in mice suggests. Read More

Drugs that target “epigenetic” changes may help treat or slow the progression of lung cancer. Read More

A protein involved in repairing DNA damage associated with gastric reflux may play a tumor suppressor role in the esophagus and could represent a target for therapies to combat esophageal cancer. Read More

Therapeutic agents focusing on the brain region involved in stress-induced relapse may be effective in preventing relapse in patients with alcohol use disorders. Read More

A strain of mutant mice provide a novel model for studying glucose intolerance and gestational diabetes during pregnancy and suggest that certain molecules may be useful for therapeutic applications. Read More

In addition to body mass index, genetic markers of obesity may provide value in predicting endometrial cancer risk. Read More

Managing myocardial infarction – and the resulting heart failure – remains a clinical challenge. To search for chemicals that can stimulate cardiac muscle cell production, Vanderbilt Institute of Chemical Biology investigators led by Tao Zhong, Ph.D., Terri Ni, Ph.D., and Eric Rellinger, M.D., turned to a novel drug discovery tool:… Read More

Images of individuals with Alagille syndrome (National Institutes of Health) Mutations in the Jagged1 gene cause Alagille syndrome, an inherited disorder that affects the liver, heart, kidneys and facial structure. Patients with Alagille syndrome often have a prominent forehead, a flattened midface and a prominent chin; some have a cleft… Read More

About half of kidney patients will die from heart disease within five years of starting dialysis, yet patients with kidney failure are rarely included in heart disease research. Jorge Gamboa, M.D., T. Alp Ikizler, M.D., and Nancy Brown, M.D., completed a small study that suggests a more personalized approach to… Read More

Tea and its phytochemical constituents have demonstrated anti-cancer properties in cell and animal experiments – particularly green tea, which has higher levels of antioxidant polyphenols than other types of tea. iStockphoto.com Gong Yang, M.D., MPH, and colleagues evaluated the association between green tea consumption and colorectal cancer risk in participants… Read More

Ela Knapik, associate professor of medicine, and colleagues are using zebrafish to explore the molecular and cellular mechanisms that cause birth defects of the face and skeleton. Read More

(Benedict Campbell/Wellcome Images) Mitosis, or the separation of chromosomes during cell division, is driven by dynamic interactions between the kinetochore region on chromosomes and string-like structures called microtubules. A number of proteins, including the enzyme Cdk1, regulate these interactions, but it is unclear what kinetochore components such enzymes work… Read More

Young bone marrow cells alleviate aging-related kidney changes in mice. Read More

Protein helps ensure proper division of chromosomes during cell division. Read More

Host cell protein may be a target for strategies to limit spread of virus-induced squamous cell cancers. Read More

Compounds developed at Vanderbilt could offer a whole new way to treat atherosclerosis. Read More

Even when lung operations for suspected cancer resection results in a benign diagnosis, there still may be significant benefits to the procedure, new research suggests. Read More